Rhein lysinate decreases inflammation and adipose infiltration in KK/HlJ diabetic mice with non-alcoholic fatty liver disease

J Wei, YZ Zhen, J Cui, FL He, T Shen, G Hu… - Archives of pharmacal …, 2016 - Springer
The objective of this study was to investigate the protective effects of rhein lysinate (RHL) on
the liver. Mice were divided into four groups: C57BL/J control, the KK/HlJ diabetic model …

The protection of Rhein lysinate to liver in diabetic mice induced by high-fat diet and streptozotocin

YJ Lin, G Hu, KJ Li, YF Zhao, J Wei, YZ Zhen - Archives of pharmacal …, 2015 - Springer
Rhein lysinate (RHL) is the salt of lysine and rhein and the objective of this study was to
investigate the protection of RHL to liver in diabetic mice. The model of type 2 diabetes was …

Rhein ameliorates fatty liver disease through negative energy balance, hepatic lipogenic regulation, and immunomodulation in diet-induced obese mice

X Sheng, M Wang, M Lu, B Xi… - American Journal of …, 2011 - journals.physiology.org
Nonalcoholic fatty liver disease (NAFLD) is associated with obesity, insulin resistance, and
inflammatory disorders. In this study, we tested the effect of rhein, a lipophilic anthraquinone …

Therapeutical effects of rhein on nonalcoholic steatohepatitis in rats

R LI, W YING, C ZHU - Chinese Journal of Clinical …, 2007 - manu41.magtech.com.cn
AIM: To explore the therapeutic effect of rhein in rats with nonalcoholic steatohepatitis and its
possible mechanism. METHODS: 24 male SD rats were randomly divided into 3 groups after …

The anti-obesity effects of rhein on improving insulin resistance (IR) and blood lipid levels are involved in endoplasmic reticulum stress (ERs), inflammation, and …

L Ji, H Gu - Bioengineered, 2021 - Taylor & Francis
Rhein extensive biological effects including anti-inflammatory, antioxidant stress, and
improving glucose and lipid metabolism. In the present study, the effects of rhein were …

[HTML][HTML] Ameliorative effects of lutein on non-alcoholic fatty liver disease in rats

X Qiu, DH Gao, X Xiang, YF Xiong, TS Zhu… - World journal of …, 2015 - ncbi.nlm.nih.gov
AIM: To investigate the therapeutic effects of lutein against non-alcoholic fatty liver disease
(NAFLD) and the related underlying mechanism. METHODS: After 9 d of acclimation to a …

[HTML][HTML] Alkannin inhibited hepatic inflammation in diabetic Db/Db mice

W Xue, Z Fan, Y Li, L Li, T Zhang, J Lu, B Ma… - Cellular Physiology and …, 2018 - karger.com
Background/Aims: The current study was designed to investigate the protective role of
alkannin (ALK) on liver injury in diabetic C57BL/KsJ-db/db mice and explore its potential …

[HTML][HTML] Lycium ruthenicum extract alleviates high-fat diet-induced nonalcoholic fatty liver disease via enhancing the AMPK signaling pathway

J Lin, Y Zhang, X Wang… - Molecular Medicine …, 2015 - spandidos-publications.com
Nonalcoholic fatty liver disease (NAFLD) is a common liver disease that currently has no
standard treatment. The present study aimed to evaluate the effects of Lycium ruthenicum …

Salidroside attenuates high‐fat diet‐induced nonalcoholic fatty liver disease via AMPK‐dependent TXNIP/NLRP3 pathway

T Zheng, X Yang, W Li, Q Wang, L Chen… - Oxidative medicine …, 2018 - Wiley Online Library
Our previous studies suggested that salidroside could alleviate hepatic steatosis in type 2
diabetic C57BLKS/Leprdb (db/db) mice. The aim of the present study was to evaluate the …

Linarin enriched extract attenuates liver injury and inflammation induced by high‐fat high‐cholesterol diet in rats

ZJ Zhuang, CW Shan, B Li, MX Pang… - Evidence‐Based …, 2017 - Wiley Online Library
The aim of this study was to explore the potential beneficial effects of linarin enriched Flos
Chrysanthemi extract (Lin‐extract) on nonalcoholic steatohepatitis (NASH) induced by high …