Background Elevated serum ferritin with/without HFE variants in asymptomatic persons
leads frequently to referral for blood donation. Hemochromatosis (p. C282Y/p. C282Y) only …

SUMMARY Background/Objective The standard medical therapy for haemochromatosis is
iron removal by regular phlebotomy. Current guidelines suggest that this blood should be …

Early detection of individuals with hereditary hemochromatosis (HH) is important to manage
iron levels and prevent future organ damage. Although the HFE mutations that cause most …

Results The mean volume of red blood cells removed in each EA was 275 ml, with a median
reduction of 23 g/l for haemoglobin and 55 microg/l for serum ferritin levels (vs. 17 microg/l …

Background and Objectives Despite the obligate iron loss from blood donation, some donors
present with hyperferritinaemia that can result from a wide range of acute and chronic …

Frequent blood donors become iron deficient. HFE mutations are present in over 30% of
donors. A 24‐month study of 888 first time/reactivated donors and 1537 frequent donors …

We analysed iron biomarkers and their relationships in 30 subjects with HFE mutations and
moderate hyperferritinaemia undergoing iron removal at our blood donation centre. Body …

Background and Objectives Haemochromatosis (HC) is a disorder of iron metabolism,
requiring frequent phlebotomy to normalize high serum iron levels. There is currently no …

The aim of this study was to analyze the role of HFE mutations in blood donors with iron
parameters suggesting iron overload, taking into account the regional distribution of HFE …

Normal iron stores in healthy men are about 1000 mg, whereas in healthy females only
about 300 mg. A whole‐blood donation depletes the donor of approximately 225–250 mg of …