Impact of Lactational Exposure to Polychlorinated Biphenyl Causes Epigenetic Modification and Impairs Sertoli Cells Functional Regulators in F1 Progeny

E Sugantha Priya, T Sathish Kumar, P Raja Singh… - Reproductive …, 2018 - Springer
Polychlorinated biphenyl (PCB) is an endocrine-disrupting chemical. Sertoli cells (SCs)
provide physical and nutritional support for developing germ cells. Dysfunction in SCs has …

Lactational exposure effect of polychlorinated biphenyl on rat Sertoli cell markers and functional regulators in prepuberal and puberal F1 offspring

E Sugantha Priya, T Sathish Kumar, S Balaji… - Journal of …, 2017 - Springer
Abstract Purpose Polychlorinated biphenyls (PCBs) are persistent and bioaccumulative
environmental toxicants acting as endocrine disruptors. Many researches evidenced that …

Lactational exposure of polychlorinated biphenyls impair Leydig cellular steroidogenesis in F1 progeny rats

SK Thangavelu, SP Elaiyapillai, I Ramachandran… - Reproductive …, 2018 - Elsevier
The present study was aimed to determine the effects of lactational exposure of PCBs
(Aroclor 1254) on Leydig cellular steroidogenesis in F 1 progeny rats. Lactating dams were …

Effects of in utero exposure to Bisphenol A or diethylstilbestrol on the adult male reproductive system

J LaRocca, A Boyajian, C Brown… - … Research Part B …, 2011 - Wiley Online Library
The objective of this study was to determine whether in utero exposure to Bisphenol A (BPA)
induced reproductive tract abnormalities in the adult male testis. Using the C57/Bl6 mouse …

Lactational exposure of polychlorinated biphenyls downregulates critical genes in Leydig cells of F1 male progeny (PND 21)

T Sathish Kumar, E Sugantha Priya, P Raja Singh… - Andrologia, 2017 - Wiley Online Library
Polychlorinated biphenyls (PCB s) are environmental contaminants. The present study was
aimed to test the effect of lactational exposure of PCB s on Leydig cellular mRNA and …

[HTML][HTML] Gestational exposure to bisphenol A affects testicular morphology, germ cell associations, and functions of spermatogonial stem cells in male offspring

PC Karmakar, JS Ahn, YH Kim, SE Jung… - International Journal of …, 2020 - mdpi.com
Exposure to bisphenol A (BPA) in the gestational period damages the reproductive health of
offspring; detailed evidence regarding BPA-induced damage in testicular germ cells of …

[HTML][HTML] Expression of genes involved in early cell fate decisions in human embryos and their regulation by growth factors

SJ Kimber, SF Sneddon, DJ Bloor, AM El-Bareg… - …, 2008 - rep.bioscientifica.com
Persistent organochlorine pollutants (POPs) are ubiquitous, bioaccumulative compounds
with potential endocrine-disrupting effects. They cross the placental barrier thereby resulting …

[PDF][PDF] Bisphenol A alters differentiation of Leydig cells in the rabbit fetal testis

AP Ortega-García, V Díaz-Hernández… - Int. J. Dev. Biol, 2021 - academia.edu
The endocrine disruptor Bisphenol A (BPA) crosses the placental barrier and reaches the
fetal organs, including the gonads. In the testis, fetal Leydig cells (FLC) produce testosterone …

Bisphenol a affects endometrial stromal cells decidualization, involvement of epigenetic regulation

Y Xiong, X Wen, H Liu, M Zhang, Y Zhang - The Journal of steroid …, 2020 - Elsevier
Bisphenol A (BPA) is one of the most widespread endocrine disruptors in the environment
and is associated with reproductive diseases. In this study, we focused on the correlation …

Prenatal and postnatal exposure to polychlorinated biphenyls alter follicle numbers, gene expression, and a proliferation marker in the rat ovary

M Kathy, Y Lee, A Safar, MJ Laws, DD Meling… - Reproductive …, 2023 - Elsevier
Polychlorinated biphenyls (PCBs) were used in industrial applications until they were
banned in the 1970s, but they still persist in the environment. Little is known about the long …