Hereditary prostate cancer (HPC) is characterized by familial clustering of prostate cancer,
particularly father, brothers, or in a vertical generation in families, as well as early-onset of …

PURPOSE Recently developed clinical guidelines suggest that men in families with specific
cancer syndromes, such as hereditary breast and ovarian cancer (HBOC), consider genetic …

Prostate cancer is the most commonly diagnosed cancer among men in the United States as
well as most Western countries. A significant proportion of men report having a positive …

Prostate cancer (PrCa) ranks among the top five cancers for both incidence and mortality
worldwide. A significant proportion of PrCa susceptibility has been attributed to inherited …

Hereditary prostate cancer has the highest hereditary rate in men cancers. Genes
associated with hereditary prostate cancer susceptibility include mismatch repair genes …

A significant proportion of prostate cancer diagnoses may be associated with a strong
hereditary component. Men who have multiple single‐gene polymorphisms and a family …

Prostate cancer is the most common cancer in men and the second highest cause of cancer-
related mortality in the UK A genetic component in predisposition to prostate cancer has …

One of the triumphs of molecular genetics during the past two decades has been the
elucidation of the molecular mechanisms responsible for the inherited predisposition for a …

Genetic testing for prostate cancer is rapidly growing and is increasingly being driven by
precision medicine. Rates of germline pathogenic variants have been reported in up to 15 …

Purpose We describe the pathogenic variant spectrum and identify predictors of positive
results among men referred for clinical genetic testing for prostate cancer. Methods One …