Objective: Volutrauma and atelectrauma promote ventilator-induced lung injury, but their
relative contribution to inflammation in ventilator-induced lung injury is not well established …

Objectives: Ventilator-induced lung injury has substantive impact on mortality of patients with
acute respiratory distress syndrome. Although low tidal volume ventilation has been shown …

Objectives: To determine the impact of positive end-expiratory pressure during mechanical
ventilation with and without spontaneous breathing activity on regional lung inflammation in …

We examined the hypothesis that injurious ventilatory strategies (large tidal volume [Vt]
and/or low positive end-expiratory pressure [PEEP]) would increase release of inflammatory …

Volutrauma and atelectrauma have been proposed as mechanisms of ventilator-associated
lung injury, but few studies have compared their relative importance in mediating lung injury …

Objective: In acute lung injury, recruitment maneuvers have been used to open collapsed
lungs and set positive end-expiratory pressure, but their effectiveness may depend on the …

Recruitment maneuvers (RM), consisting of sustained inflations at high airway pressures,
have been advocated as an adjunct to mechanical ventilation in acute respiratory distress …

Objectives: The biologic effects of variable ventilation may depend on the etiology of acute
respiratory distress syndrome. We compared variable and conventional ventilation in …

Objective: To investigate the effects of the rate of increase in airway pressure and duration of
lung recruitment maneuvers in experimental pulmonary and extrapulmonary acute lung …

Objective Previous animal studies have shown that certain modes of mechanical ventilation
(MV) can injure the lungs. Most of those studies were performed with models that differ from …