Purpose The goal of the study was to compare the effects of different assisted ventilation
modes with pressure controlled ventilation (PCV) on lung histology, arterial blood gases …

Alveolar overdistention and cyclic reopening of collapsed alveoli have been implicated in
the lung damage found in animals submitted to artificial ventilation. To test whether these …

Objective: To investigate the effects of the rate of airway pressure increase and duration of
recruitment maneuvers on lung function and activation of inflammation, fibrogenesis, and …

Objective: Tidal volume (VT) and volume of gas caused by positive end-expiratory pressure
(V PEEP) generate dynamic and static lung strains, respectively. Our aim was to clarify …

Ventilator-induced lung injury (VILI) is a significant risk for patients with acute respiratory
distress syndrome (ARDS). Management of the patient with ARDS is currently dominated by …

We tested the hypothesis that, under relatively low tidal volume (Vt) mechanical ventilation,
continuing lung decruitment induced by negative end-expiratory pressure (NEEP) would …

During mechanical ventilation, lung recruitment attenuates injury caused by high VT,
improves oxygenation, and may optimize pulmonary vascular resistance (PVR). We …

Objectives: Determine the intra-tidal regional gas and blood volume distributions at different
levels of atelectasis in experimental lung injury. Test the hypotheses that pulmonary aeration …

Mechanical ventilation using inappropriate settings can produce acute parenchymal lung
injury and an acute inflammatory response in the lung. The associated release of cytokines …

16]. Little, however, is known about the pathophysiological mechanisms of the obvious
linkage between VALI, multiple-organ failure, and patient outcome. The coincidence of …