Aberrant activation of beta-catenin/TCF signaling is one of the hallmarks of colon cancer. It is
of great interest to study the mechanism for the regulation of beta-catenin/TCF signaling. In …

Low density lipoprotein (LDL) receptor-related protein-6 (LRP6) is an important co-receptor
of Wnt pathway, which plays a predominant role in development and progression of …

The overactivation of canonical Wnt/β‐catenin pathway and the maintenance of cancer stem
cells (CSCs) are essential for the onset and malignant progression of most human cancers …

BACKGROUND Our previous study demonstrated that RBBP4 was upregulated in colon
cancer and correlated with poor prognosis of colon cancer and hepatic metastasis …

The Wnt signaling pathway plays key roles in both embryogenesis and tumorigenesis. The
low-density lipoprotein (LDL) receptor-related protein-6 (LRP6), a novel member of the …

Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) is an established
cancer stem cell marker and is a target gene of the Wnt/β‑catenin signaling pathway, a …

The interaction between Axin and DVL2 is critical for the breaking down of the beta‐catenin
destruction complex and the activation of the Wnt/beta‐catenin cascade. However, this …

The overactivation of canonical Wnt/β-catenin pathway is one of the main cascades for the
initiation, progression, and recurrence of most human malignancies. As an indispensable …

It has been reported that estrogen receptors (ERs) participate in carcinogenesis by directly
regulating NOD-like receptors (NLRs). However, the expression profiles of ERs and NLRs in …

Background Emerging evidence has shown long noncoding RNAs (lncRNAs) exert
important roles in colorectal cancer (CRC) tumorigenesis. However, most lncRNAs involved …