The tumor suppressor P53 plays critical role in preventing cancer. P53 is rarely mutated and
remains functional in luminal-type breast cancer (1). According to current knowledge, wild …

To identify novel oncogenic E3 ubiquitin ligases as anticancer targets, we screened an E3
ubiquitin ligase siRNA library containing siRNA pools against 555 individual E3s using the …

Background/Aims: Although early studies show that Mdm2 is the primary E3 ubiquitin ligase
for the p53 tumor suppressor, an increasing amount of data suggests that p53 ubiquitination …

The atypical E3 ubiquitin ligase RNF31 is highly expressed in human breast cancer, the
most frequent neoplastic lethality among women. Here, RNF31 depletion in breast cancer …

The selective ubiquitination of proteins by ubiquitin E3 ligases plays an important regulatory
role in control of cell differentiation, growth, and transformation and their dysregulation is …

The oncoprotein MDM2 is an E3 ubiquitin ligase that targets tumor suppressor p53 for
ubiquitination and proteasomal degradation, restraining the potent activity of p53 and …

The E3 ubiquitin ligase ring finger protein 115 (RNF 115) is overexpressed in more than half
of human breast tumors and is implicated in the pathogenesis and progression of breast …

Breast cancer causes the No. 1 women cancer prevalence and the No. 2 women cancer
mortality worldwide. Nuclear receptor/transcriptional factor signaling is aberrant and plays …

Lung adenocarcinoma (LAC) represents approximately 40% of all lung cancer cases and is
the leading cause of cancer-associated mortality worldwide. Although combined treatment …

Deregulation of E3 ubiquitin ligases is intimately implicated in breast cancer pathogenesis
and progression, but the underlying mechanisms still remain elusive. Here we report that …