Inhibition of xanthine oxidase in the acute phase of myocardial infarction prevents skeletal muscle abnormalities and exercise intolerance
H Nambu, S Takada, S Maekawa… - Cardiovascular …, 2021 - academic.oup.com
Aims Exercise intolerance in patients with heart failure (HF) is partly attributed to skeletal
muscle abnormalities. We have shown that reactive oxygen species (ROS) play a crucial …
muscle abnormalities. We have shown that reactive oxygen species (ROS) play a crucial …
Chronic xanthine oxidase inhibition following myocardial infarction in rabbits: effects of early versus delayed treatment
L Zhao, BM Roche, JL Wessale, A Kijtawornrat, JL Lolly… - Life Sciences, 2008 - Elsevier
Xanthine oxidase (XO) expression is increased in the failing heart, and animal studies in
rodents and dogs showed that XO inhibition with allopurinol can improve left ventricular (LV) …
rodents and dogs showed that XO inhibition with allopurinol can improve left ventricular (LV) …
Xanthine oxidoreductase inhibition causes reverse remodeling in rats with dilated cardiomyopathy
KM Minhas, RM Saraiva, KH Schuleri, S Lehrke… - Circulation …, 2006 - Am Heart Assoc
Increased reactive oxygen species (ROS) generation is implicated in cardiac remodeling in
heart failure (HF). As xanthine oxidoreductase (XOR) is 1 of the major sources of ROS, we …
heart failure (HF). As xanthine oxidoreductase (XOR) is 1 of the major sources of ROS, we …
Inhibition of xanthine oxidase improves myocardial contractility in patients with ischemic cardiomyopathy
S Baldus, K Müllerleile, P Chumley, D Steven… - Free Radical Biology …, 2006 - Elsevier
Reactive oxygen species, in particular superoxide, have been closely linked to the
underlying pathophysiology of ischemic cardiomyopathy: superoxide not only mediates …
underlying pathophysiology of ischemic cardiomyopathy: superoxide not only mediates …
Xanthine oxidase inhibition and heart failure: novel therapeutic strategy for ventricular dysfunction?
RJ Hajjar, JA Leopold - Circulation research, 2006 - Am Heart Assoc
Myocardial dysfunction and heart failure perturb cardio-vascular homeostatic signaling
pathways as well as initiate a program of molecular, biochemical, and structural …
pathways as well as initiate a program of molecular, biochemical, and structural …
Febuxostat pretreatment attenuates myocardial ischemia/reperfusion injury via mitochondrial apoptosis
S Wang, Y Li, X Song, X Wang, C Zhao, A Chen… - Journal of translational …, 2015 - Springer
Background Febuxostat is a selective inhibitor of xanthine oxidase (XO). XO is a critical
source of reactive oxygen species (ROS) during myocardial ischemia/reperfusion (I/R) …
source of reactive oxygen species (ROS) during myocardial ischemia/reperfusion (I/R) …
Allopurinol attenuates left ventricular remodeling and dysfunction after experimental myocardial infarction: a new action for an old drug?
N Engberding, S Spiekermann, A Schaefer… - Circulation, 2004 - Am Heart Assoc
Background—Accumulating evidence suggests a critical role for increased reactive oxygen
species (ROS) production in left ventricular (LV) remodeling and dysfunction after …
species (ROS) production in left ventricular (LV) remodeling and dysfunction after …
Xanthine oxidase inhibitors improve energetics and function after infarction in failing mouse hearts
AV Naumova, VP Chacko… - American Journal …, 2006 - journals.physiology.org
After myocardial infarction, ventricular geometry and function, as well as energy metabolism,
change markedly. In nonischemic heart failure, inhibition of xanthine oxidase (XO) improves …
change markedly. In nonischemic heart failure, inhibition of xanthine oxidase (XO) improves …
Existence and participation of xanthine oxidase in reperfusion injury of ischemic rabbit myocardium
LS Terada, JD Rubinstein… - American Journal …, 1991 - journals.physiology.org
Using a highly specific assay that minimizes enzyme inactivation in vitro, we found that
rabbit myocardial tissue contained low levels of xanthine oxidase (XO) and xanthine …
rabbit myocardial tissue contained low levels of xanthine oxidase (XO) and xanthine …
Novel insights into interactions between mitochondria and xanthine oxidase in acute cardiac volume overload
JD Gladden, BR Zelickson, CC Wei, E Ulasova… - Free Radical Biology …, 2011 - Elsevier
Xanthine oxidoreductase (XOR) is increased in the left ventricle (LV) of humans with volume
overload (VO), and mitochondrial inhibition of the respiratory chain occurs in animal models …
overload (VO), and mitochondrial inhibition of the respiratory chain occurs in animal models …