Further optimization of the β-aminoester class of factor Xa (fXa) inhibitors is described
culminating in the identification of 9c (FXV673), a potent and selective factor Xa inhibitor with …

Background: Factor Xa (FXa) is known to play a central role in blood coagulation cascade
and considered to be one of the most attractive targets for oral anticoagulants of new …

Intravascular clot formation is an important factor in a number of cardiovascular diseases.
Therefore, the prevention of blood coagulation has become a major target for new …

Abstract A series of pyrrolo [3, 2-d] pyrimidineone compounds have been designed and
synthesized as novel FXa inhibitors. Bioassay of the tested compounds showed moderate to …

Thromboembolic diseases such as deep vein thrombosis (DVT), pulmonary embolism (PE),
myocardial infarction (MI) and ischemic strokes are mainly responsible for people's morbidity …

To develop a potent and oral anticoagulant, a series of compounds with cinnamyl moiety
was synthesized and their factor Xa (FXa) inhibitory activities were examined. As a result …

Our exploratory study was based on the concept that a non-amidine factor Xa (fXa) inhibitor
is suitable for an orally available anticoagulant. We synthesized and evaluated a series of N …

Based on the both of results for X-ray studies of tetrahydrothiazolopyridine derivative 1c and
FXV673, we synthesized a series of thiazol-5-ylpyridine derivatives containing pyridine N …

Intravascular clot formation is an important event in a number of cardiovascular diseases.
The prevention of blood coagulation has become a major target for new therapeutic agents …

Abstract Factor Xa (FXa) is a serine protease that plays key roles in linking the intrinsic and
extrinsic coagulation pathways to the final common pathway. DJT06001 is an oral, highly …