Mitochondrial Dysfunction and Alpha‐Lipoic Acid: Beneficial or Harmful in Alzheimer's Disease?

SM Dos Santos, CFR Romeiro… - Oxidative medicine …, 2019 - Wiley Online Library
Alzheimer's disease (AD) is a neurodegenerative disorder characterised by impairments in
the cognitive domains associated with orientation, recording, and memory. This pathology …

[图书][B] α-Lipoic acid as a new treatment option for Alzheimer's disease—A 48 months follow-up analysis

K Hager, M Kenklies, J McAfoose, J Engel, G Münch - 2007 - Springer
Oxidative stress and neuronal energy depletion are characteristic biochemical hallmarks of
Alzheimer's disease (AD). It is therefore conceivable that pro-energetic and antioxidant …

Decrypting the potential role of α-lipoic acid in Alzheimer's disease

D Kaur, T Behl, A Sehgal, S Singh, N Sharma… - Life Sciences, 2021 - Elsevier
Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases with
motor disturbances, cognitive decline, and behavioral impairment. It is characterized by the …

The effects and mechanisms of mitochondrial nutrient α-lipoic acid on improving age-associated mitochondrial and cognitive dysfunction: an overview

J Liu - Neurochemical research, 2008 - Springer
We have identified a group of nutrients that can directly or indirectly protect mitochondria
from oxidative damage and improve mitochondrial function and named them “mitochondrial …

Lipoic acid as an anti-inflammatory and neuroprotective treatment for Alzheimer's disease

A Maczurek, K Hager, M Kenklies, M Sharman… - Advanced drug delivery …, 2008 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that destroys patient
memory and cognition, communication ability with the social environment and the ability to …

Lipoic acid as a novel treatment for Alzheimer's disease and related dementias

L Holmquist, G Stuchbury, K Berbaum, S Muscat… - Pharmacology & …, 2007 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that destroys patient
memory and cognition, communication ability with the social environment and the ability to …

α-Lipoic acid, functional fatty acid, as a novel therapeutic alternative for central nervous system diseases: A review

F Seifar, M Khalili, H Khaledyan… - Nutritional …, 2019 - Taylor & Francis
Objectives: α-lipoic acid (ALA) is a natural antioxidant which acts as a cofactor of
bioenergetic mitochondrial enzymes. Along with its mitochondrial action, ALA and its …

[HTML][HTML] Redox active α-lipoic acid differentially improves mitochondrial dysfunction in a cellular model of alzheimer and its control cells

F Dieter, C Esselun, GP Eckert - International journal of molecular …, 2022 - mdpi.com
Introduction: Alpha lipoic acid (ALA) is a sulphur-containing organic compound, derived from
octanoic acid, and an important cofactor for mitochondrial respiratory enzymes. It has strong …

Alpha-lipoic acid as a new treatment option for Azheimer type dementia

K Hager, A Marahrens, M Kenklies, P Riederer… - Archives of gerontology …, 2001 - Elsevier
Oxidative stress and energy depletion are characteristic biochemical hallmarks of
Alzheimer's disease (AD), thus antioxidants with positive effects on glucose metabolism …

Mitochondrion-specific antioxidants as drug treatments for Alzheimer disease

HH Palacios, BB Yendluri… - CNS & Neurological …, 2011 - ingentaconnect.com
Age-related dementias such as Alzheimer disease (AD) have been linked to vascular
disorders like hypertension, diabetes and atherosclerosis. These risk factors cause …