Morphological changes in melanized and non-melanized Cryptococcus neoformans cells post exposure to sparsely and densely ionizing radiation demonstrate …

ME Malo, RA Bryan, I Shuryak, E Dadachova - Fungal biology, 2018 - Elsevier
There is a need for novel and effective prophylactic treatments and radioprotective materials
to protect civilians and military personnel from ionizing radiation in contaminated …

Assessing melanin capabilities in radiation shielding and radioadaptation

ME Malo, C Frank, E Dadachova - Journal of Medical Imaging and …, 2019 - jmirs.org
There is a need in creating efficient and light weight radioprotectors which would protect
against both sparsely and densely ionizing radiation for use in radiation therapy, nuclear …

Protection of Melanized Cryptococcus neoformans from Lethal Dose Gamma Irradiation Involves Changes in Melanin's Chemical Structure and Paramagnetism

A Khajo, RA Bryan, M Friedman, RM Burger… - PLoS …, 2011 - journals.plos.org
Certain fungi thrive in highly radioactive environments including the defunct Chernobyl
nuclear reactor. Cryptococcus neoformans (C. neoformans), which uses L-3, 4 …

The radioprotective properties of fungal melanin are a function of its chemical composition, stable radical presence and spatial arrangement

E Dadachova, RA Bryan, RC Howell… - Pigment cell & …, 2008 - Wiley Online Library
Melanized microorganisms are often found in environments with very high background
radiation levels such as in nuclear reactor cooling pools and the destroyed reactor in …

Melanin is effective in protecting fast and slow growing fungi from various types of ionizing radiation

C Pacelli, RA Bryan, S Onofri… - Environmental …, 2017 - Wiley Online Library
Melanin is a ubiquitous pigment with unique physicochemical properties. The resistance of
melanized fungi to cosmic and terrestrial ionizing radiation suggests that melanin also plays …

Transcriptomic analysis reveals the relationship of melanization to growth and resistance to gamma radiation in Cryptococcus neoformans

Z Schultzhaus, A Chen, S Kim, I Shuryak… - Environmental …, 2019 - Wiley Online Library
The pathogenic fungus Cryptococcus neoformans produces melanin within its cell wall for
infection and resistance against external stresses such as exposure to UV, temperature …

The effect of protracted X‐ray exposure on cell survival and metabolic activity of fast and slow growing fungi capable of melanogenesis

C Pacelli, RA Bryan, S Onofri… - Environmental …, 2018 - Wiley Online Library
The aim of this study was to analyse how protracted exposure to X‐rays delivered at low
dose rates of 0.0032–0.052 kGy h− 1 affects the survival and metabolic activity of two …

Variability in UVB Tolerances of Melanized and Nonmelanized Cells of Cryptococcus neoformans and C. laurentii

LA Schiave, RS Pedroso, RC Candido… - Photochemistry and …, 2009 - Wiley Online Library
Solar radiation is one of the major factors responsible for the control of fungus populations in
the environment. Inactivation by UVA and UVB radiation is especially important for the …

Decreased susceptibility of melanized Cryptococcus neoformans to UV light

Y Wang, A Casadevall - Applied and environmental microbiology, 1994 - Am Soc Microbiol
Decreased Susceptibility of Melanized Cryptococcus neoformans to UV Light Page 1
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Oct. 1994, p. 3864-3866 0099-2240/94/$04.00+0 …

Melanin as an energy transducer and a radioprotector in black fungi

ME Malo, E Dadachova - Fungi in extreme environments: ecological role …, 2019 - Springer
Scope: Melanin is an ancient and unique pigment that can be found in all phyla of the fungi
kingdom. The presence of melanin imparts a selective advantage to fungi promoting survival …