Abstract According to the World Health Organization, the consumption of tobacco products is
the single largest cause of preventable deaths in the world, exceeding the total aggregated …

A liquid chromatography–electrospray ionization–tandem mass spectrometry (HPLC–ESI+–
MS/MS) method for the analysis of the tobacco-specific carcinogens N′-nitrosonornicotine …

Biomarkers of exposure to harmful tobacco constituents are key tools for identifying
individuals at risk and developing interventions and tobacco control measures. However …

A new method was developed and validated for the simultaneous determination of nicotine
and tobacco-specific nitrosamines (TSNAs) 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone …

Two of the most widely measured compounds in the urine of people who use tobacco
products are cotinine, a major metabolite of the addictive constituent nicotine, and 4 …

Background The tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-
butanone (NNK), is formed from nicotine and related compounds during tobacco curing and …

ABSTRACT A liquid chromatography tandem mass spectrometry (LC/MS/MS) method was
developed and validated for the determination of five total tobacco‐specific N‐nitrosamines …

We developed a stable isotope dilution ultra-performance liquid chromatography–
electrospray ionization tandem mass spectrometry assay to measure nicotine and cotinine …

A method was developed for the efficient determination of nicotine and cotinine in rat plasma
samples originating from nicotine exposure studies. Nicotine and cotinine were extracted …

A rapid and selective assay of nicotine, cotinine and rans-3'-hydroxycotinine in human
serum, based on high-performance liquid chromatography with UV detection has been …