It is thought that rewarding experiences with drugs create strong contextual associations and
encourage repeated intake. In turn, repeated exposures to drugs of abuse make lasting …

Neural and physiological factors underlying individual differences in the vulnerability to drug
abuse are the major questions remained to be determined. The present study described …

Conditioned place preference and locomotor sensitization are rodent behavioral models
commonly used to investigate the actions of drugs of abuse. However, few studies have …

Background The potential of abused drugs to induce addiction and compulsive drug-related
behavior is associated with their ability to alter dopamine signaling. Dopamine plays a key …

The development and maintenance of cocaine addiction depend heavily on learned reward-
environment associations that can induce drug-seeking behavior and relapse …

The present protocol describes the Conditioned Place Preference (CPP) as a model of
relapse in drug addiction. In this model, animals are first trained to acquire a conditioned …

Rationale Drug addiction is a multifactorial disorder resulting from an interaction between
genetic and environmental factors, and negative and positive environmental conditions may …

Cocaine use disorders (CUD) are devastating for affected individuals and impose a
significant societal burden, but there are currently no FDA-approved therapies. The …

Rationale Rats develop preferences for places associated with the immediate rewarding
effects of cocaine and aversions for places paired with the drug's delayed negative effects …

Background The expanding set of genomics tools available for inbred mouse strains has
renewed interest in phenotyping larger sets of strains. The present study aims to explore …