Purpose Asthma is a disease of increasing worldwide importance that calls for new
investigative methods. Ex vivo lung tissue is being increasingly used to study functional …

Ex vivo rodent lung models are explored for physiological measurements of respiratory
function with hyperpolarized (hp) 129Xe MRI. It is shown that excised lung models allow for …

Despite a myriad of technical advances in medical imaging, as well as the growing need to
address the global impact of pulmonary diseases, such as asthma and chronic obstructive …

Purpose To develop a breathhold acquisition for regional mapping of ventilation and the
fractions of hyperpolarized xenon‐129 (Xe129) dissolved in tissue (lung parenchyma and …

Many forms of lung disease manifest themselves as pathological changes in the transport of
gas to the circulatory system, yet the difficulty of imaging this process remains a central …

Hyperpolarized 129 Xe magnetic resonance imaging is a powerful modality capable of
assessing lung structure and function. While it has shown promise as a clinical tool for the …

RATIONALE AND OBJECTIVES: Quantitative regional measurement of physiological
parameters of lung may improve both early detection of asthma and its response to …

Background Individuals with asthma can vary widely in clinical presentation, severity, and
pathobiology. Hyperpolarized xenon‐129 (Xe129) MRI is a novel imaging method to provide …

Purpose To implement and optimize a single‐shot spiral encoding strategy for rapid 2D
IDEAL projection imaging of hyperpolarized (Hp) 129Xe in the gas phase, and in the …

Purpose: We investigated the feasibility of 3D hyperpolarized (HP) 129 Xe magnetic
resonance (MR) imaging at an extremely low concentration of HP 129 Xe supplied from a …