Trials and tribulations of MicroRNA therapeutics

AA Seyhan - International Journal of Molecular Sciences, 2024 - mdpi.com
The discovery of the link between microRNAs (miRNAs) and a myriad of human diseases,
particularly various cancer types, has generated significant interest in exploring their …

Innovative approaches in transforming microRNAs into therapeutic tools

AFA Samad, MF Kamaroddin - Wiley Interdisciplinary Reviews …, 2023 - Wiley Online Library
MicroRNA (miRNA) is regarded as a prominent genetic regulator, as it can fine‐tune an
entire biological pathway by targeting multiple target genes. This characteristic makes …

MicroRNA therapeutics: towards a new era for the management of cancer and other diseases

R Rupaimoole, FJ Slack - Nature reviews Drug discovery, 2017 - nature.com
In just over two decades since the discovery of the first microRNA (miRNA), the field of
miRNA biology has expanded considerably. Insights into the roles of miRNAs in …

miRNA-based therapeutic strategies

M Ishida, FM Selaru - Current Pathobiology Reports, 2013 - Springer
Micro-RNAs (miRNAs) are short, non-coding RNA species, thought to act primarily through
downregulation of target mRNA species with subsequent decrease in encoded proteins …

The challenges and opportunities in the development of MicroRNA therapeutics: a multidisciplinary viewpoint

MY Momin, RR Gaddam, M Kravitz, A Gupta, A Vikram - Cells, 2021 - mdpi.com
microRNAs (miRs) are emerging as attractive therapeutic targets because of their small size,
specific targetability, and critical role in disease pathogenesis. However,< 20 miR targeting …

Developing therapeutic microRNAs for cancer

AG Bader, D Brown, J Stoudemire, P Lammers - Gene therapy, 2011 - nature.com
Despite substantial progress in understanding the cancer-signaling network, effective
therapies remain scarce due to insufficient disruption of oncogenic pathways, drug …

MicroRNAs in cancer therapeutics: “from the bench to the bedside

PC Monroig-Bosque, CA Rivera… - Expert opinion on …, 2015 - Taylor & Francis
MicroRNAs (miRNAs) are non-coding RNA transcripts that regulate physiological processes
by targeting proteins directly. Their involvement in research has been robust, and evidence …

microRNAs as novel therapeutics in cancer

G Romano, M Acunzo, P Nana-Sinkam - Cancers, 2021 - mdpi.com
Simple Summary Over the last few years, we have witnessed incredible advancements in
anti-tumor drug development. microRNAs, a class of small non-coding RNAs dysregulated …

The road toward microRNA therapeutics

AG Seto - The international journal of biochemistry & cell biology, 2010 - Elsevier
Within the last 15 years, microRNAs (miRNAs) have emerged as powerful regulators of gene
expression. Highly conserved, these small RNAs appear to regulate nearly every aspect of …

MicroRNAs as newer therapeutic targets: A big hope from a tiny player

HS Ghelani, MA Rachchh… - … of Pharmacology and …, 2012 - journals.sagepub.com
MicroRNAs (miRNAs) are a novel group of universally present small noncoding
endogenous RNAs that regulate gene expression and protein coding by base pairing with …