OBJECTIVE: α-Linolenic acid (ALA), the vegetable n-3 fatty acid, appears to have
antiatherosclerotic properties akin to those of marine n-3 fatty acids. A prior study in a US …

Background: Epidemiologic evidence shows an inverse relation between fish consumption
and death from ischemic heart disease. This beneficial effect is attributed to n− 3 fatty acids …

Background The cardioprotective ability of n-3 polyunsaturated fatty acids (PUFAs) is
controversial. Most studies suggest a specific role for PUFAs in cardioprotection from …

Background Whereas dietary intake of long-chain n− 3 fatty acids has been associated with
risk of nonfatal myocardial infarction (MI), few studies have examined the relation for blood …

The essentiality of the n-6 fatty acid, linoleic acid, was established about 80 years ago (1, 2);
the essentiality of the n-3 analogue, a-linolenic acid, became accepted rather later (3, 4) …

Plant-derived alpha-linolenic acid has been studied in a limited number of investigations. So
far, some epidemiologic and a few mechanistic studies suggest a potential of protection from …

Background: Guidelines advocate changes in fatty acid consumption to promote
cardiovascular health. Purpose: To summarize evidence about associations between fatty …

Background Only a limited number of studies have examined the vascular and postprandial
effects of α-linolenic acid (ALA, C18: 3n-3). Therefore, we performed a well-controlled trial …

Dietary intake of marine n-3 PUFA has been negatively associated with the risk of CHD
among subjects with known CHD, whereas an effect in healthy subjects is less documented …

Plants provide α-linolenic acid [ALA; 18: 3n–3 (18: 3ω-3)], which can be converted via
eicosapentaenoic acid (EPA; 20: 5n–3) to docosahexaenoic acid (DHA; 22: 6n–3), which is …