Phase 3 trial of defibrotide for the treatment of severe veno-occlusive disease and multi-organ failure

PG Richardson, ML Riches, NA Kernan… - Blood, The Journal …, 2016 - ashpublications.org
Hepatic veno-occlusive disease (VOD), also called sinusoidal obstruction syndrome (SOS),
is a potentially life-threatening complication of hematopoietic stem cell transplantation …

[HTML][HTML] Defibrotide for the treatment of hepatic veno-occlusive disease: final results from the international compassionate-use program

S Corbacioglu, E Carreras, M Mohty, A Pagliuca… - Biology of Blood and …, 2016 - Elsevier
Hepatic veno-occlusive disease, also called sinusoidal obstruction syndrome (VOD/SOS), is
an unpredictable and potentially fatal complication of hematopoietic cell transplantation …

Systematic review of defibrotide studies in the treatment of veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS)

P Richardson, S Aggarwal, O Topaloglu… - Bone Marrow …, 2019 - nature.com
Abstract Veno-occlusive disease (VOD), also called sinusoidal obstruction syndrome (SOS),
is a potentially life-threatening complication of hematopoietic stem cell transplantation …

Hepatic veno-occlusive disease after hematopoietic stem cell transplantation: update on defibrotide and other current investigational therapies

VT Ho, C Revta, PG Richardson - Bone marrow transplantation, 2008 - nature.com
Hepatic veno-occlusive disease (VOD), also known as sinusoidal obstruction syndrome
(SOS), remains one of the most serious and common complications after myeloablative …

Final results from a defibrotide treatment‐IND study for patients with hepatic veno‐occlusive disease/sinusoidal obstruction syndrome

NA Kernan, S Grupp, AR Smith, S Arai… - British journal of …, 2018 - Wiley Online Library
Hepatic veno‐occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) is a potentially
life‐threatening complication of haematopoietic stem cell transplant (HSCT) conditioning …

Earlier defibrotide initiation post‐diagnosis of veno‐occlusive disease/sinusoidal obstruction syndrome improves Day+ 100 survival following haematopoietic stem cell …

PG Richardson, AR Smith, BM Triplett… - British journal of …, 2017 - Wiley Online Library
Hepatic veno‐occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) is a
progressive, potentially fatal complication of conditioning for haematopoietic stem cell …

Drug safety evaluation of defibrotide

PG Richardson, S Corbacioglu, VTV Ho… - Expert opinion on …, 2013 - Taylor & Francis
Introduction: Hepatic veno-occlusive disease (VOD), also known as sinusoidal obstruction
syndrome (SOS), is a potentially life-threatening complication of chemotherapeutic …

The use of defibrotide in blood and marrow transplantation

PG Richardson, E Carreras, M Iacobelli… - Blood …, 2018 - ashpublications.org
Hepatic veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) is a potentially
life-threatening complication of conditioning during hematopoietic stem cell transplantation …

Multi-institutional use of defibrotide in 88 patients after stem cell transplantation with severe veno-occlusive disease and multisystem organ failure: response without …

PG Richardson, C Murakami, Z Jin… - Blood, The Journal …, 2002 - ashpublications.org
Veno-occlusive disease (VOD) is the most common regimen-related toxicity accompanying
stem cell transplantation (SCT). Severe VOD complicated by multisystem organ failure …

[HTML][HTML] Defibrotide for the treatment of severe hepatic veno-occlusive disease and multiorgan failure after stem cell transplantation: a multicenter, randomized, dose …

PG Richardson, RJ Soiffer, JH Antin, H Uno… - Biology of Blood and …, 2010 - Elsevier
Therapeutic options for severe hepatic veno-occlusive disease (VOD) are limited and
outcomes are dismal, but early phase I/II studies have suggested promising activity and …