Reactive nitrogen species (RNS) are formed when there is an abnormal increase in the level
of nitric oxide (NO) produced by the inducible nitric oxide synthase (iNOS) and/or by the …

Adaptation of the heart to intrinsic and external stress involves complex modifications at the
molecular and cellular levels that lead to tissue remodeling, functional and metabolic …

There is growing evidence that altered production and/or spatio‐temporal distribution of
reactive oxidant species and reactive nitrosative species in blood creates oxidative and/or …

Heart failure is the major cause of hospitalization, morbidity and mortality worldwide.
Previous experimental and clinical studies have suggested that there is an increased …

Reactive oxygen species (ROS) are generated by several different cellular sources, and
their accumulation within the myocardium is widely considered to cause harmful oxidative …

Reactive nitrogen species (RNS) are various nitric oxide–derived compounds, including
nitroxyl anion, nitrosonium cation, higher oxides of nitrogen, S-nitrosothiols, and dinitrosyl …

Nitrosative stress, as an important oxygen metabolism disorder, has been shown to be
closely associated with cardiovascular diseases, such as myocardial ischemia/reperfusion …

It is well documented that metabolic syndrome (ie a group of risk factors, such as abdominal
obesity, elevated blood pressure, elevated fasting plasma glucose, high serum triglycerides …

Nitric oxide (NO) is an imperative regulator of the cardiovascular system and is a critical
mechanism in preventing the pathogenesis and progression of the diseased heart. The …

The understanding of nitric oxide (NO) signaling has grown substantially since the
identification of endothelial derived relaxing factor (EDRF). NO has emerged as a ubiquitous …