The latest scientific findings in the field of cancer research are redefining our understanding
of the molecular and cellular basis of the disease, moving the emphasis toward the study of …

B‐cell acute lymphoblastic leukaemia (B‐ALL) is a clonal malignant disease originated in a
single cell and characterized by the accumulation of blast cells that are phenotypically …

B-cell acute lymphoblastic leukemia (B-ALL) is a hematological disorder characterized by
malignant and uncontrolled proliferation of B-lymphoid precursor cells in bone marrow. Over …

Simple Summary Acute lymphoblastic leukemia is a heterogeneous disease characterized
by a diversity of genetic alterations, following a sophisticated and controversial organization …

Discoveries of the underlying biological pathways that drive leukemogenesis in children
have taken place at an astonishing pace. These findings have resulted in large part because …

B-lymphocyte development in the bone marrow is controlled by the coordinated action of
transcription factors creating regulatory networks ensuring activation of the B-lymphoid …

Human B-lymphopoiesis is a dynamic life-long process that starts in utero by around six post-
conception weeks. A detailed understanding of human fetal B-lymphopoiesis and how it …

B-lymphocyte differentiation is one of the best understood developmental pathways in the
hematopoietic system. Our understanding of the developmental trajectories linking the …

B-cell precursor acute lymphoblastic leukemias (pB-ALLs) are the most frequent type of
malignancies of the childhood, and also affect an important proportion of adult patients. In …

We examined the leukemic stem cell potential of blasts at different stages of maturation in
childhood acute lymphoblastic leukemia (ALL). Human leukemic bone marrow was …