Despite the importance of dynamic changes in the regional distributions of gas and blood
during the breathing cycle for lung function in the mechanically ventilated patient, no …

More than 50 years ago, John West and colleagues (1) published their landmark study on
the vertical distribution of blood flow in the lung as a result of the interplay between the local …

A respiration-gated synchrotron radiation computed tomography (SRCT) technique, which
allows visualization and direct quantification of inhaled stable xenon gas, was used to study …

The beating heart is known to produce pressure and airflow oscillations in the lungs of
mammals. This phenomenon is often disregarded as detailed measurement of its effects in …

Objective: To assess the effects of positive end-expiratory pressure on regional ventilation
distribution in normal lung and after histamine-induced bronchoconstriction. Design …

The aim of this study was to assess the feasibility of a novel respiration-gated spiral
synchrotron radiation computed tomography (SRCT) technique for direct quantification of …

During breathing, lung inflation is a dynamic process involving a balance of mechanical
factors, including trans-pulmonary pressure gradients, tissue compliance and airway …

Ventilation is inhomogeneous in the lungs across species. It has been hypothesized that
ventilation inhomogeneity is largely determined by the design of the airway branching …

Despite nearly a half century of studies, it has not been fully understood how pulmonary
alveoli, the elementary gas exchange units in mammalian lungs, inflate and deflate during …

Modern ventilatory strategies are based on the assumption that lung terminal airspaces act
as isotropic balloons that progressively accommodate gas. Phase contrast synchrotron …