The magnitude and distribution of strain imposed on the peripheral airspaces by mechanical
ventilation at the microscopic level and the consequent deformations are unknown despite …

Introduction The mechanisms of lung inflation and deflation are only partially known.
Ventilatory strategies to support lung function rely upon the idea that lung alveoli are …

Background It is not well known what is the main mechanism causing lung heterogeneity in
healthy lungs under mechanical ventilation. We aimed to investigate the mechanisms …

There is a growing interest in imaging techniques as non-invasive means of quantitatively
measuring regional lung structure and function. Abnormalities in lung ventilation due to …

Small airways play a key role in the distribution of ventilation and in the matching of
ventilation to perfusion. The purpose of this study was to introduce an imaging method that …

Structural and functional changes of pulmonary circulation related to pathophysiology of
pulmonary arterial hypertension (PAH) remain to be fully elucidated. Angiographic …

Purpose: This feasibility study in healthy animals should prove the concept that it is possible
to quantitatively assess the effects of different ventilatory settings on the lung parenchyma …

The role of imaging as a tool for investigating lung physiology is growing at an accelerating
pace. Looking forward, we wished to identify unresolved issues in lung physiology that might …

In this study, we aim to quantify the differences in lung metrics measured in free‐breathing
and mechanically ventilated rodents using respiratory‐gated micro‐computed tomography …

Mechanical ventilation can damage the lungs, a condition called Ventilator-Induced Lung
Injury (VILI). However, the mechanisms leading to VILI at the microscopic scale remain …