A computational analysis of in vivo VEGFR activation by multiple co-expressed ligands
LE Clegg, F Mac Gabhann - PLoS computational biology, 2017 - journals.plos.org
The splice isoforms of vascular endothelial growth A (VEGF) each have different affinities for
the extracellular matrix (ECM) and the coreceptor NRP1, which leads to distinct vascular …
the extracellular matrix (ECM) and the coreceptor NRP1, which leads to distinct vascular …
Site-specific phosphorylation of VEGFR2 is mediated by receptor trafficking: insights from a computational model
LW Clegg, F Mac Gabhann - PLoS computational biology, 2015 - journals.plos.org
Matrix-binding isoforms and non-matrix-binding isoforms of vascular endothelial growth
factor (VEGF) are both capable of stimulating vascular remodeling, but the resulting blood …
factor (VEGF) are both capable of stimulating vascular remodeling, but the resulting blood …
Modeling of growth factor-receptor systems: from molecular-level protein interaction networks to whole-body compartment models
FTH Wu, MO Stefanini, F Mac Gabhann… - Methods in enzymology, 2009 - Elsevier
Most physiological processes are subjected to molecular regulation by growth factors, which
are secreted proteins that activate chemical signal transduction pathways through binding of …
are secreted proteins that activate chemical signal transduction pathways through binding of …
Systems biology of pro‐angiogenic therapies targeting the VEGF system
Vascular endothelial growth factor (VEGF) is a family of cytokines for which the
dysregulation of expression is involved in many diseases; for some, excess VEGF causes …
dysregulation of expression is involved in many diseases; for some, excess VEGF causes …
Dimerization of VEGF receptors and implications for signal transduction: a computational study
F Mac Gabhann, AS Popel - Biophysical chemistry, 2007 - Elsevier
Vascular endothelial growth factor (VEGF) is a potent cytokine involved in the induction of
neovascularization. Secreted as a cysteine-linked dimer, it has two binding sites at opposite …
neovascularization. Secreted as a cysteine-linked dimer, it has two binding sites at opposite …
Trafficking dynamics of VEGFR1, VEGFR2, and NRP1 in human endothelial cells
S Sarabipour, K Kinghorn, KM Quigley… - PLOS Computational …, 2024 - journals.plos.org
The vascular endothelial growth factor (VEGF) family of cytokines are key drivers of blood
vessel growth and remodeling. These ligands act via multiple VEGF receptors (VEGFR) and …
vessel growth and remodeling. These ligands act via multiple VEGF receptors (VEGFR) and …
Quantification and cell-to-cell variation of vascular endothelial growth factor receptors
PI Imoukhuede, AS Popel - Experimental cell research, 2011 - Elsevier
The vascular endothelial growth factor receptors (VEGFR) play a significant role in
angiogenesis, the formation of new blood vessels from existing vasculature. Systems …
angiogenesis, the formation of new blood vessels from existing vasculature. Systems …
Systems biology of vascular endothelial growth factors
FM Gabhann, AS Popel - Microcirculation, 2008 - Taylor & Francis
Several cytokine families have roles in the development, maintenance, and remodeling of
the microcirculation. Of these, the vascular endothelial growth factor (VEGF) family is one of …
the microcirculation. Of these, the vascular endothelial growth factor (VEGF) family is one of …
Targeting neuropilin-1 to inhibit VEGF signaling in cancer: comparison of therapeutic approaches
FM Gabhann, AS Popel - PLoS computational biology, 2006 - journals.plos.org
Angiogenesis (neovascularization) plays a crucial role in a variety of physiological and
pathological conditions including cancer, cardiovascular disease, and wound healing …
pathological conditions including cancer, cardiovascular disease, and wound healing …
A two-compartment model of VEGF distribution in the mouse
Vascular endothelial growth factor (VEGF) is a key regulator of angiogenesis–the growth of
new microvessels from existing microvasculature. Angiogenesis is a complex process …
new microvessels from existing microvasculature. Angiogenesis is a complex process …