Systems pharmacology of VEGF165b in peripheral artery disease
We built a whole‐body computational model to study the role of the poorly understood
vascular endothelial growth factor (VEGF) 165b splice isoform in peripheral artery disease …
vascular endothelial growth factor (VEGF) 165b splice isoform in peripheral artery disease …
Differential binding of VEGF isoforms to VEGF receptor 2 in the presence of neuropilin-1: a computational model
F Mac Gabhann, AS Popel - American Journal of …, 2005 - journals.physiology.org
A comprehensive, biophysically accurate, computational model of vascular endothelial
growth factor (VEGF) family member interactions with endothelial cell surface receptors was …
growth factor (VEGF) family member interactions with endothelial cell surface receptors was …
Computational kinetic model of VEGF trapping by soluble VEGF receptor-1: effects of transendothelial and lymphatic macromolecular transport
FTH Wu, MO Stefanini, F Mac Gabhann… - Physiological …, 2009 - journals.physiology.org
Vascular endothelial growth factor (VEGF) signal transduction through the cell surface
receptors VEGFR1 and VEGFR2 regulates angiogenesis—the growth of new capillaries …
receptors VEGFR1 and VEGFR2 regulates angiogenesis—the growth of new capillaries …
[HTML][HTML] The presence of VEGF receptors on the luminal surface of endothelial cells affects VEGF distribution and VEGF signaling
MO Stefanini, FTH Wu, F Mac Gabhann… - PLoS computational …, 2009 - journals.plos.org
Vascular endothelial growth factor (VEGF) is a potent cytokine that binds to specific
receptors on the endothelial cells lining blood vessels. The signaling cascade triggered …
receptors on the endothelial cells lining blood vessels. The signaling cascade triggered …
[HTML][HTML] Formation of VEGF isoform-specific spatial distributions governing angiogenesis: computational analysis
P Vempati, AS Popel, F Mac Gabhann - BMC systems biology, 2011 - Springer
Background The spatial distribution of vascular endothelial growth factor A (VEGF) is an
important mediator of vascular patterning. Previous experimental studies in the mouse …
important mediator of vascular patterning. Previous experimental studies in the mouse …
[HTML][HTML] A compartment model of VEGF distribution in humans in the presence of soluble VEGF receptor-1 acting as a ligand trap
Vascular endothelial growth factor (VEGF), through its activation of cell surface receptor
tyrosine kinases including VEGFR1 and VEGFR2, is a vital regulator of stimulatory and …
tyrosine kinases including VEGFR1 and VEGFR2, is a vital regulator of stimulatory and …
Quantification of VEGFRs, NRP1, and PDGFRs on endothelial cells and fibroblasts reveals serum, intra-family ligand, and cross-family ligand regulation
Computational modeling of angiogenesis is limited by a lack of experimental data on
angiogenic receptor levels. Recent receptor profiling quantified vascular endothelial growth …
angiogenic receptor levels. Recent receptor profiling quantified vascular endothelial growth …
[HTML][HTML] Monte Carlo simulations of VEGF binding to cell surface receptors in vitro
The vascular endothelial growth factor (VEGF) family binds multiple endothelial cell surface
receptors. Our goal is to build comprehensive models of these interactions for the purpose of …
receptors. Our goal is to build comprehensive models of these interactions for the purpose of …
[引用][C] Computational systems biology for the VEGF family in angiogenesis
JC Weddell, PI Imoukhuede - 2018 - Elsevier
Interactions of VEGF isoforms with VEGFR-1, VEGFR-2, and neuropilin in vivo: a computational model of human skeletal muscle
FM Gabhann, AS Popel - American Journal of Physiology …, 2007 - journals.physiology.org
The vascular endothelial growth factor (VEGF) family of cytokines is involved in the
maintenance of existing adult blood vessels as well as in angiogenesis, the sprouting of new …
maintenance of existing adult blood vessels as well as in angiogenesis, the sprouting of new …