Angiogenesis, the formation of new blood vessels from existing vasculature, is important in
tumor growth and metastasis. A key regulator of angiogenesis is vascular endothelial growth …

The ability to control vascular endothelial growth factor (VEGF) signaling offers promising
therapeutic potential for vascular diseases and cancer. Despite this promise, VEGF-targeted …

Vascular endothelial growth factor (VEGF) signal transduction is central to angiogenesis in
development and in pathological conditions such as cancer, retinopathy and ischemic …

Vascular endothelial growth factors (VEGFs) bind to membrane receptors on a wide variety
of cells to regulate diverse biological responses. The VEGF-A family member promotes …

Angiogenesis, the formation of new blood vessels from pre-existing ones, is essential for
both normal development and numerous pathologies. Systems biology has offered a unique …

Pathologic angiogenesis is mediated by the coordinated action of the vascular endothelial
growth factor (VEGF)/vascular endothelial growth factor receptor 2 (VEGFR2) signaling axis …

Background Angiogenesis is a process by which new capillaries are formed from pre-
existing blood vessels in physiological (eg, exercise, wound healing) or pathological (eg …

Background Vascular endothelial growth factor (VEGF) is known to be a potent promoter of
angiogenesis under both physiological and pathological conditions. Given its role in …

Placental growth factor (PlGF) competes with vascular endothelial growth factor (VEGF) for
binding to VEGF receptor (VEGFR)-1 but does not bind VEGFR2. Experiments show that …

Tumor growth and progression are critically dependent on the establishment of a vascular
support system. This is often accomplished via the expression of pro-angiogenic growth …