Background Vascular endothelial growth factor (VEGF) is known to be a potent promoter of
angiogenesis under both physiological and pathological conditions. Given its role in …

Placental growth factor (PlGF) competes with vascular endothelial growth factor (VEGF) for
binding to VEGF receptor (VEGFR)-1 but does not bind VEGFR2. Experiments show that …

Tumor growth and progression are critically dependent on the establishment of a vascular
support system. This is often accomplished via the expression of pro-angiogenic growth …

Experimental data indicates that soluble vascular endothelial growth factor (VEGF) receptor
1 (sFlt-1) modulates the guidance cues provided to sprouting blood vessels by VEGF-A. To …

Abstract Vascular Endothelial Growth Factor (VEGF) signal transduction is central to
angiogenesis in development and in pathological conditions such as cancer, retinopathy …

Introduction: Angiogenesis was first proposed as a possible target for the treatment of
human cancer several decades ago. During recent years, the discovery of VEGF as the main …

The vascular endothelial growth factor receptor 2 (VEGFR-2) is a member of receptor
tyrosine kinases (RTKs) and is a dimeric membrane protein that functions as a primary …

We present an analysis of a stochastic model of the vascular endothelial growth factor
(VEGF) receptor. This analysis addresses the contribution of ligand-binding-induced …

Nearly all studies of angiogenesis have focused on uni-family ligand-receptor binding, eg,
VEGFs bind to VEGF receptors, PDGFs bind to PDGF receptors, etc. The discovery of VEGF …

Vascular endothelial growth factor-A (VEGF-A) is a crucial member of the Vascular
endothelial growth factor (VEGF) family which mediates the metastasis of tumor by …