Comparative structure‐function analysis of VEGFR‐1 and VEGFR‐2: What have we learned from chimeric systems?
RD Meyer, N Rahimi - Annals of the New York Academy of …, 2003 - Wiley Online Library
Activation of vascular endothelial growth factor receptor‐1 and‐2 (VEGFR‐1 and VEGFR‐2)
plays a critical role in vasculogenesis and angiogenesis. However, the mechanism by which …
plays a critical role in vasculogenesis and angiogenesis. However, the mechanism by which …
Quantitative fluorescent profiling of VEGFR s reveals tumor cell and endothelial cell heterogeneity in breast cancer xenografts
PI Imoukhuede, AS Popel - Cancer medicine, 2014 - Wiley Online Library
Plasma membrane‐localized vascular endothelial growth factor receptors (VEGFR) play a
critical role in transducing VEGF signaling toward pro and antiangiogenic outcomes and …
critical role in transducing VEGF signaling toward pro and antiangiogenic outcomes and …
Predicting the effects of anti-angiogenic agents targeting specific VEGF isoforms
Vascular endothelial growth factor (VEGF) is a key mediator of angiogenesis, whose effect
on cancer growth and development is well characterized. Alternative splicing of VEGF leads …
on cancer growth and development is well characterized. Alternative splicing of VEGF leads …
Quantitative characterization of cellular membrane-receptor heterogeneity through statistical and computational modeling
JC Weddell, PI Imoukhuede - PloS one, 2014 - journals.plos.org
Cell population heterogeneity can affect cellular response and is a major factor in drug
resistance. However, there are few techniques available to represent and explore how …
resistance. However, there are few techniques available to represent and explore how …
Structure–function analysis of VEGF receptor activation and the role of coreceptors in angiogenic signaling
FS Grünewald, AE Prota, A Giese… - Biochimica et Biophysica …, 2010 - Elsevier
Vascular endothelial growth factors (VEGFs) constitute a family of six polypeptides, VEGF-A,-
B,-C,-D,-E and PlGF, that regulate blood and lymphatic vessel development. VEGFs …
B,-C,-D,-E and PlGF, that regulate blood and lymphatic vessel development. VEGFs …
Exploring the intracrine functions of VEGF-A
S Wiszniak, Q Schwarz - Biomolecules, 2021 - mdpi.com
Vascular endothelial growth factor A (VEGF-A or VEGF) is a highly conserved secreted
signalling protein best known for its roles in vascular development and angiogenesis. Many …
signalling protein best known for its roles in vascular development and angiogenesis. Many …
A systems biology perspective on sVEGFR1: its biological function, pathogenic role and therapeutic use
FTH Wu, MO Stefanini, FM Gabhann… - Journal of cellular …, 2010 - Wiley Online Library
Introduction‐Angiogenesis in physiology and pathology‐Angiogenesis in current medicine‐
VEGF ligand and receptor system: where does sVEGFR1 fit?‐Ligands: the human VEGF …
VEGF ligand and receptor system: where does sVEGFR1 fit?‐Ligands: the human VEGF …
VEGF-A/VEGFR2 signaling network in endothelial cells relevant to angiogenesis
CS Abhinand, R Raju, SJ Soumya, PS Arya… - Journal of cell …, 2016 - Springer
Vascular endothelial growth factor-A (VEGF-A) is essential for endothelial cell functions
associated with angiogenesis. Signal transduction networks initiated by VEGFA/VEGFR2 …
associated with angiogenesis. Signal transduction networks initiated by VEGFA/VEGFR2 …
Unraveling the influence of endothelial cell density on VEGF-A signaling
L Napione, S Pavan, A Veglio, A Picco… - Blood, The Journal …, 2012 - ashpublications.org
Vascular endothelial growth factor-A (VEGF) is the master determinant for the activation of
the angiogenic program leading to the formation of new blood vessels to sustain solid tumor …
the angiogenic program leading to the formation of new blood vessels to sustain solid tumor …
Chimeric VEGFRs are activated by a small-molecule dimerizer and mediate downstream signalling cascades in endothelial cells
EL Knight, AJ Warner, A Maxwell, SA Prigent - Oncogene, 2000 - nature.com
Despite much interest in vascular endothelial growth factor (VEGF) and its receptors
(VEGFRs-1 and-2), VEGF-induced signalling cascades remain incompletely defined …
(VEGFRs-1 and-2), VEGF-induced signalling cascades remain incompletely defined …