[HTML][HTML] Epitope-Based Vaccines against the Chlamydia trachomatis Major Outer Membrane Protein Variable Domain 4 Elicit Protection in Mice

AL Collar, AC Linville, SB Core, KM Frietze - Vaccines, 2022 - mdpi.com
Chlamydia trachomatis (Ct) is the most common bacterial sexual transmitted pathogen, yet a
vaccine is not currently available. Here, we used the immunogenic bacteriophage MS2 virus …

Immunization with a peptide corresponding to chlamydial heat shock protein 60 increases the humoral immune response in C3H mice to a peptide representing …

VL Motin, LM de la Maza… - Clinical Diagnostic …, 1999 - Am Soc Microbiol
ABSTRACT C3H (H-2k) mice are susceptible to a vaginal challenge with human strains of
Chlamydia trachomatis and thus are a useful strain for testing potential Chlamydia vaccine …

Chlamydia trachomatis polymorphic membrane protein D is a species-common pan-neutralizing antigen

DD Crane, JH Carlson, ER Fischer… - Proceedings of the …, 2006 - National Acad Sciences
Infections caused by the obligate intracellular pathogen Chlamydia trachomatis have a
marked impact on human health. C. trachomatis serovariants are the leading cause of …

[HTML][HTML] Seventy years of Chlamydia vaccine research–limitations of the past and directions for the future

S Phillips, BL Quigley, P Timms - Frontiers in microbiology, 2019 - frontiersin.org
Chlamydia is a major bacterial pathogen that infects humans, as well as a wide range of
animals, including marsupials, birds, cats, pigs, cattle, and sheep. Antibiotics are the only …

[HTML][HTML] Identification of novel antigens for the development of a vaccine to prevent sexually transmitted chlamydia infections

CL McNeilly - 2006 - eprints.qut.edu.au
Chlamydia trachomatis infections are among the most frequently reported causes of human
sexually transmitted infection. In Australia, the reported rate of infection in 2004 reached 175 …

Plasmid-encoded Pgp3 is a major virulence factor for Chlamydia muridarum to induce hydrosalpinx in mice

Y Liu, Y Huang, Z Yang, Y Sun, S Gong… - Infection and …, 2014 - Am Soc Microbiol
Hydrosalpinx induction in mice by Chlamydia muridarum infection, a model that has been
used to study C. trachomatis pathogenesis in women, is known to depend on the cryptic …

[HTML][HTML] Chlamydia trachomatis Cross-Serovar Protection during Experimental Lung Reinfection in Mice

C Lanfermann, M Kohn, R Laudeley, C Rheinheimer… - Vaccines, 2021 - mdpi.com
Chlamydia trachomatis causes most bacterial sexually transmitted diseases worldwide.
Different major outer membrane proteins (MOMPs) define various serovars of this …

Comparison of intranasal and transcutaneous immunization for induction of protective immunity against Chlamydia muridarum respiratory tract infection

KA Skelding, DK Hickey, JC Horvat, S Bao, KG Roberts… - Vaccine, 2006 - Elsevier
Chlamydia pneumoniae causes a range of respiratory infections including bronchitis,
pharyngitis and pneumonia. Infection has also been implicated in exacerbation/initiation of …

Induction of protection in mice against a respiratory challenge by a vaccine formulated with the Chlamydia major outer membrane protein adjuvanted with IC31®

C Cheng, MI Cruz-Fisher, D Tifrea, S Pal, B Wizel… - Vaccine, 2011 - Elsevier
IC31®, a novel adjuvant, has been shown to be effective by increasing the levels of IFN-γ in
animal models when delivered with several antigens. Here, we tested the ability of IC31®, to …

Differential expression of Pmp10 in cell culture infected with Chlamydia pneumoniae CWL029

AS Pedersen, G Christiansen… - FEMS microbiology …, 2001 - academic.oup.com
The complete genome of Chlamydia pneumoniae contains a total of 21 genes encoding
polymorphic membrane proteins (Pmp). From this large Pmp family three genes, pmp8 …