[HTML][HTML] Noradrenergic genes polymorphisms and response to methylphenidate in children with ADHD: a systematic review and meta-analysis

D Yuan, M Zhang, Y Huang, X Wang, J Jiao, Y Huang - Medicine, 2021 - journals.lww.com
Background: Attention-deficit hyperactivity disorder (ADHD) is the most common childhood-
onset neurodevelopmental disorder, and methylphenidate (MPH) is considered one of the …

[HTML][HTML] The alpha-2A adrenergic receptor gene-1291C/G single nucleotide polymorphism is associated with the efficacy of methylphenidate in treating Taiwanese …

HC Huang, LSH Wu, SC Yu, BJ Wu, AC Lua… - Psychiatry …, 2018 - ncbi.nlm.nih.gov
Objective The therapeutic effect of methylphenidate (MPH) in treating attention-
deficit/hyperactivity disorder (ADHD) has been related to the alpha-2A adrenergic receptor …

[HTML][HTML] A candidate gene investigation of methylphenidate response in adult attention-deficit/hyperactivity disorder patients: results from a naturalistic study

TA Hegvik, KK Jacobsen, M Fredriksen… - Journal of Neural …, 2016 - Springer
Attention-deficit/hyperactivity disorder (ADHD) is a common childhood onset
neuropsychiatric disorder with a complex and heterogeneous symptomatology. Persistence …

Association between homozygosity of a G allele of the alpha-2a-adrenergic receptor gene and methylphenidate response in Korean children and adolescents with …

KA Cheon, DY Cho, MS Koo, DH Song… - Biological psychiatry, 2009 - Elsevier
BACKGROUND: Methylphenidate (MPH) blocks the norepinephrine transporter as well as
the dopamine transporter. The α-2a-adrenergic receptor is a key component of the …

Attention-deficit/hyperactivity disorder: advancing on pharmacogenomics

G Polanczyk, C Zeni, JP Genro, T Roman, MH Hutz… - 2005 - Future Medicine
Attention-deficit/hyperactivity disorder (ADHD) is a highly prevalent psychiatric disorder. An
impressive volume of literature documents both a strong participation of genetics in its …

Pharmacogenetics predictors of methylphenidate efficacy in childhood ADHD

NM Myer, JR Boland, SV Faraone - Molecular psychiatry, 2018 - nature.com
Stimulant medication has long been effective in treating attention-deficit/hyperactivity
disorder (ADHD) and is currently the first-line pharmacological treatment for children. Both …

No significant association between the alpha-2A-adrenergic receptor gene and treatment response in combined or inattentive subtypes of attention-deficit …

S Park, JW Kim, BN Kim, SB Hong, MS Shin… - …, 2013 - thieme-connect.com
Given the shortage of pharmacogenetic studies on treatment response according to subtype
of attention-deficit hyperactivity disorder (ADHD), we investigated the associations between …

Dopaminergic and noradrenergic gene polymorphisms and response to methylphenidate in korean children with attention-deficit/hyperactivity disorder: is there an …

SB Hong, JW Kim, SC Cho, MS Shin… - Journal of Child and …, 2012 - liebertpub.com
Objective: We aimed to investigate the independent and interaction effects of dopamine
transporter gene (DAT1), dopamine D4 receptor gene (DRD4), alpha-2A adrenergic …

Norepinephrine transporter− 3081 (A/T) and alpha-2A-adrenergic receptor MspI polymorphisms are associated with cardiovascular side effects of OROS …

SC Cho, BN Kim, TDR Cummins… - Journal of …, 2012 - journals.sagepub.com
The purpose of this study was to investigate a possible association between norepinephrine
genes and cardiovascular side effects of the Osmotic Controlled-Release Oral Delivery …

Genetic influence on efficacy of pharmacotherapy for pediatric attention-deficit/hyperactivity disorder: overview and current status of research

NA Elsayed, KM Yamamoto, TE Froehlich - CNS drugs, 2020 - Springer
Multiple stimulant and non-stimulant medications are approved for the treatment of attention-
deficit/hyperactivity disorder (ADHD), one of the most prevalent childhood …