Apart from the well-established role of kisspeptin (Kp) in the regulation of reproductive
functions, recent data described its action in the control of metabolism. Of particular interest …

Kisspeptin has recently been identified as a key neuroendocrine gatekeeper of reproduction
and is essential for the initiation of human puberty and maintenance of adult reproduction …

Results The kisspeptin system (KISS1/G protein-coupled receptor-54, GPR54) has recently
been addressed as an essential gatekeeper of puberty onset and gonadotropin secretion …

Recent data indicates that kisspeptin, encoded by the KISS1 gene, could play a role in
transducing metabolic information into the hypothalamic–pituitary–gonadal (HPG) axis, the …

Kisspeptin (KP) is now well recognized as a potent stimulator of gonadotropin-releasing
hormone (GnRH) secretion and thereby a major regulator of the neuroendocrine …

Kisspeptin, encoded by KISS1/Kiss1 gene, is now considered a master regulator of
reproductive functions in mammals owing to its involvement in the direct activation of …

Activation of the gonadotropic axis critically depends on sufficient body energy stores, and
conditions of negative energy balance result in lack of puberty onset and reproductive …

Kisspeptins are a group of peptide fragments encoded by the KISS1 gene in humans. They
bind to kisspeptin receptors with equal efficacy. Kisspeptins and their receptors are …

Hypothalamic KiSS-1 gene expression is critical for the maintenance of reproductive
function, and levels are attenuated by sex hormones and by food restriction, providing a link …

Hypogonadotropism is a common feature of uncontrolled diabetes, for which the ultimate
mechanism remains to be elucidated. Kisspeptins, ligands of G protein–coupled receptor 54 …