Abstract Cyclooxygenase‐2 (COX‐2) is frequently expressed in many types of cancers
exerting a pleiotropic and multifaceted role in genesis or promotion of carcinogenesis and …

It is well admitted that the link between chronic inflammation and cancer involves cytokines
and mediators of inflammatory pathways, which act during the different steps of …

Despite recent improvements in chemotherapy and radiation therapy in cancer management
with the addition of biological agents, novel treatment approaches are needed to further …

Abstract Cyclooxygenase‐2 (COX‐2) is the inducible isoform of cyclooxygenase, the
enzyme that catalyzes the rate‐limiting step in prostaglandin synthesis from arachidonic …

Epidemiologic studies have documented a 40–50% reduction in incidence of colorectal
cancer in individuals taking nonsteroidal antiinflammatory drugs (NSAIDs). Since NSAIDs …

Cyclooxygenase-2 (Cox-2) is an inducible enzyme involved in the conversion of arachidonic
acid to prostaglandin and other eicosanoids. Molecular pathology studies have revealed …

Abstract Cyclooxygenase-2 (COX-2), an inducible form of the enzyme that catalyzes the first
step in the synthesis of prostanoids, is associated with inflammatory diseases and …

Cyclooxygenase‐2 (COX‐2) is an inducible form of the enzyme that catalyses the synthesis
of prostanoids, including prostaglandin E2 (PGE2), a major mediator of inflammation and …

Compelling experimental and clinical evidence supports the notion that cyclooxygenase-2,
the inducible isoform of cyclooxygenase, plays a crucial role in oncogenesis. Clinical and …

Tumor angiogenesis is a process where new blood vessels are formed from preexisting
ones, resulting in several pathologies. Solid tumors induce angiogenesis to obtain the …