Optimal drug therapy and therapeutic drug monitoring after spinal cord injury: a population-specific approach

JL Segal, MS Pathak - American Journal of Therapeutics, 2001 - journals.lww.com
Survival after spinal cord injury (SCI), once measured in terms of weeks or months, is now
measured in years, and most survivors of SCI go on to live full lives. The quality of life …

Pharmacological management of spinal cord injury: current status of drugs designed to augment functional recovery of the injured human spinal cord

KA Greene, FF Marciano, VKH Sonntag - Clinical Spine Surgery, 1996 - journals.lww.com
Spinal cord injury often results in devastating physical, psychological, and economic
disabilities. Research efforts are directed toward providing prognostic outcome data and …

Clinical pharmacokinetics in patients with spinal cord injuries

JL Segal, SR Brunnemann - Clinical pharmacokinetics, 1989 - Springer
Although spinal cord injury is a catastrophic affliction with numerous victims and a variety of
physiological manifestations, the associated disarray in physiology has yet to be …

The experimental basis for early pharmacological intervention in spinal cord injury

RK Simpson, CY Hsu, MR Dimitrijevic - Spinal Cord, 1991 - nature.com
The major impetus of basic spinal cord injury (SCI) research is that therapeutic interventions
can be devised to prevent or reduce disability. For years, there was doubt about the prospect …

[PDF][PDF] Pathophysiological mechanisms involved in systemic and metabolic alterations secondary to spinal cord injury

G Guízar-Sahagún… - PROCEEDINGS …, 1998 - researchgate.net
Spinal cord injury (SCI) has captured the interest of different scientific and social disciplines,
as such injury in humans represents medical and socioeconomic problems of great …

Rapid quantification of tissue damage for assessing acute spinal cord injury therapy

W Young - Journal of neurotrauma, 1992 - liebertpub.com
Therecently published results of the National Acute Spinal Cord Injury Study (NASCIS II)
have complicated studies of acute spinal cord injury treatments in several ways. First …

Recent advances in the pharmacologic treatment of spinal cord injury

A Cox, A Varma, N Banik - Metabolic brain disease, 2015 - Springer
A need exists for the effective treatment of individuals suffering from spinal cord injury (SCI).
Recent advances in the understanding of the pathophysiological mechanisms occurring in …

Acute spinal cord injury, part I: pathophysiologic mechanisms

RJ Dumont, DO Okonkwo, S Verma… - Clinical …, 2001 - journals.lww.com
Spinal cord injury (SCI) is a devastating and common neurologic disorder that has profound
influences on modern society from physical, psychosocial, and socioeconomic perspectives …

[HTML][HTML] Spinal cord injury sequelae alter drug pharmacokinetics: an overview

H Mestre, T Alkon, S Salazar, A Ibarra - Spinal cord, 2011 - nature.com
Study design: Literature review. Objectives: Critical review of the literature published on the
physiological alterations caused by spinal cord injury (SCI) and their effect on the …

A grading system to evaluate objectively the strength of pre-clinical data of acute neuroprotective therapies for clinical translation in spinal cord injury

BK Kwon, EB Okon, E Tsai, MS Beattie… - Journal of …, 2011 - liebertpub.com
The past three decades have seen an explosion of research interest in spinal cord injury
(SCI) and the development of hundreds of potential therapies that have demonstrated some …