DNA is associated with proteins that are involved in its folding and transaction processes.
When cells are exposed to chemical cross-linking agents or free radical–generating ionizing …

Proteins that act on DNA, or are in close proximity to it, can become inadvertently
crosslinked to DNA and form highly toxic lesions, known as DNA-protein crosslinks (DPCs) …

DNA is constantly exposed to a wide array of genotoxic agents, generating a variety of forms
of DNA damage. DNA-protein crosslinks (DPCs)—the covalent linkage of proteins with a …

The covalent crosslinking of proteins to DNA presents a major physical challenge to the
DNA metabolic machinery. DNA–protein crosslinks (DPCs) are induced by a variety of …

When a protein is covalently and irreversibly bound to DNA (ie, a DNA–protein cross-link
[DPC]), it may obstruct any DNA-based transaction, such as transcription and replication …

DNA–protein cross-links are generated by both endogenous and exogenous DNA
damaging agents, as intermediates during normal DNA metabolism, and during abortive …

Conspectus Noncovalent DNA–protein interactions are at the heart of normal cell function. In
eukaryotic cells, genomic DNA is wrapped around histone octamers to allow for …

Covalent binding of DNA to proteins produces DNA− protein cross-links (DPCs). DPCs are
formed as intermediates of enzymatic processes, generated from the reactions of protein …

Covalent DNA–protein crosslinks (DPCs, also known as protein adducts) of topoisomerases
and other proteins with DNA are highly toxic DNA lesions. Of note, chemical agents that …

DNA–protein crosslinks (DPCs) are highly toxic DNA adducts, but whether dedicated DPC-
repair mechanisms exist was until recently unknown. This has changed with discoveries …