Soluble compounds released by hypoxic stroma confer invasive properties to pancreatic ductal adenocarcinoma
D Liu, A Steins, R Klaassen, AP van der Zalm… - Biomedicines, 2020 - mdpi.com
Pancreatic ductal adenocarcinoma (PDAC) is characterized by abundant stroma and a
hypoxic microenvironment. Pancreatic stellate cells (PSC) are activated by hypoxia and …
hypoxic microenvironment. Pancreatic stellate cells (PSC) are activated by hypoxia and …
[HTML][HTML] Unique metabolic features of pancreatic cancer stroma: relevance to the tumor compartment, prognosis, and invasive potential
Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis. The aggressiveness
and therapeutic recalcitrance of this malignancy has been attributed to multiple factors …
and therapeutic recalcitrance of this malignancy has been attributed to multiple factors …
Hypoxic stellate cells of pancreatic cancer stroma regulate extracellular matrix fiber organization and cancer cell motility
M Sada, K Ohuchida, K Horioka, T Okumura… - Cancer letters, 2016 - Elsevier
Desmoplasia and hypoxia in pancreatic cancer mutually affect each other and create a
tumor-supportive microenvironment. Here, we show that microenvironment remodeling by …
tumor-supportive microenvironment. Here, we show that microenvironment remodeling by …
Hypoxia: Friend or Foe for drug delivery in Pancreatic Cancer
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal solid tumors with
an overall five-year survival rate of that has only just reached 10%. The tumor …
an overall five-year survival rate of that has only just reached 10%. The tumor …
Hypoxia enhances the interaction between pancreatic stellate cells and cancer cells via increased secretion of connective tissue growth factor
D Eguchi, N Ikenaga, K Ohuchida, S Kozono… - Journal of Surgical …, 2013 - Elsevier
BACKGROUND: Pancreatic cancer (PC), a hypovascular tumor, thrives under hypoxic
conditions. Pancreatic stellate cells (PSCs) promote PC progression by secreting soluble …
conditions. Pancreatic stellate cells (PSCs) promote PC progression by secreting soluble …
[引用][C] Targeting tumor hypoxia with hypoxia-activated prodrugs
A hallmark of pancreatic ductal adenocarcinoma (PDA) is its dense desmoplastic stroma
and comparatively low tumor cellularity. 1, 2 The dense stroma contributes to high interstitial …
and comparatively low tumor cellularity. 1, 2 The dense stroma contributes to high interstitial …
Hypoxia induces EMT in low and highly aggressive pancreatic tumor cells but only cells with cancer stem cell characteristics acquire pronounced migratory potential
AV Salnikov, L Liu, M Platen, J Gladkich, O Salnikova… - 2012 - journals.plos.org
Tumor hypoxia induces epithelial-mesenchymal transition (EMT), which induces invasion
and metastasis, and is linked to cancer stem cells (CSCs). Whether EMT generates CSCs de …
and metastasis, and is linked to cancer stem cells (CSCs). Whether EMT generates CSCs de …
[HTML][HTML] Hypoxia-induced endoplasmic reticulum stress characterizes a necrotic phenotype of pancreatic cancer
B Kong, T Cheng, W Wu, I Regel, S Raulefs, H Friess… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Stromal fibrosis and tissue necrosis are major histological sequelae of hypoxia. The hypoxia-
to-fibrosis sequence is well-documented in pancreatic ductal adenocarcinoma (PDAC) …
to-fibrosis sequence is well-documented in pancreatic ductal adenocarcinoma (PDAC) …
Resveratrol ameliorates the malignant progression of pancreatic cancer by inhibiting hypoxia-induced pancreatic stellate cell activation
Y Xiao, T Qin, L Sun, W Qian, J Li, W Duan… - Cell …, 2020 - journals.sagepub.com
Pancreatic cancer is characterized by a hypoxic tumor microenvironment, which is primarily
caused by massive fibrosis with pancreatic stellate cells (PSCs) as a main component. Our …
caused by massive fibrosis with pancreatic stellate cells (PSCs) as a main component. Our …
Hypoxia promotes an inflammatory phenotype of fibroblasts in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is characterized by an extensive
fibroinflammatory stroma and often experiences conditions of insufficient oxygen availability …
fibroinflammatory stroma and often experiences conditions of insufficient oxygen availability …