Much progress has been made in recent years regarding enzymological aspects of
mammalian brain GAD, such as its purification and characterization, but some uncertainty …

Abstract Glutamate decarboxylase (glutamate 1-carboxylyase, EC 4.1. 1.15, GAD)* is the
major, rate-limiting enzyme in brain for synthesizing gamma-aminobutyric acid (GABA). Total …

Abstract L-Glutamate decarboxylase (GAD), the GABA-synthesizing enzyme, has been
purified to homogeneity from mouse brain, bovine brain and catfish brain by a combination …

Studies of the GABA-synthetic enzyme glutamate decarboxylase (glutamic acid
decarboxylase; GAD; EC 4.1. 1.15) began in 1951 with the work of Roberts and his …

A series of overlapping clones coding for L‐glutamic acid decarboxylase was purified from a
mouse brain cDNA library, the longest of which contains a 1869 bp open reading frame and …

L‐Glutamate decarboxylase (EC 4.1. 1.15)(GAD), the enzyme responsible for the formation
of GABA, has been purified to homogeneity from mouse brain (Wu et at., 1973) and …

Specific monoclonal and polyclonal antibodies to rat brain glutamate decar☐ ylase (GAD)
were produced and characterized. Polyclonal antibodies against GAD were raised in rabbits …

Two isoforms of glutamic acid decarboxylase (GAD67 and GAD65) and their mRNAs were
localized in the rat brain by immunohistochemistry and nonradioactive in situ hybridization …

l-Glutamate decarboxylase (GAD) which catalyzes the conversion of l-glutamate to γ-
aminobutyric acid, an important inhibitory neurotransmitter, is a specific marker for γ …

We used specific polyclonal antibodies against L-glutamate decarboxylase (GAD) to screen
a mouse brain cDNA library that was constructed in the expression vector lambda gt11. We …