The ubiquitin-proteasome system (UPS) is a selective protein degradation system that plays
a critical role in many essential biological processes by regulating the existence of various …

The transcriptional activity of hypoxia-inducible factor-1 (HIF-1) is associated with tumor
malignancies; therefore, it is important to comprehend its dynamism in solid tumors …

Abstract Purpose Hypoxia-inducible factor-1 (HIF-1) plays an important role in malignant
tumour progression. For the imaging of HIF-1-active tumours, we previously developed a …

Functional imaging has become an important tool in oncology because it not only provides
information about the size and localization of the tumour, but also about the …

Tumor hypoxia plays a crucial role in tumorigenesis. Under hypoxia, hypoxia-inducible
factor 1α (HIF-1α) regulates activation of genes promoting malignant progression. Under …

Purpose We aimed to develop a radiolabeled peptide probe for the imaging of hypoxia-
inducible factor-1 (HIF-1)-active tumors. Procedures We synthesized the peptide probes that …

Polyubiquitination signal deliver diverse cellular signal, which have been recognized as a
sophisticated ubiquitin code. The perception and transduction of ubiquitination signal …

Because tumor cells grow rapidly and randomly, hypoxic regions arise from the lack of
oxygen supply in solid tumors. Hypoxic regions in tumors are known to be resistant to …

Hypoxia is a common condition in rapidly proliferating tumors and occurs when oxygen
delivery to the tissue is scarce. It is a prevalent feature in~ 90% of solid tumors. The family of …

Background In humans, imaging of tumors provides rapid, accurate assessment of tumor
growth and location. In laboratory animals, however, the imaging of spontaneously occurring …