Given that bone turnover markers are often shipped to central laboratories, it is essential to
be aware of factors that will affect stability. We have evaluated how sample type, time before …

Bone turnover markers (BTM) provide useful data to titrate the optimal dosing regimes for
patients within 3–6 months as compared to 1–2 years using bone mineral density (BMD) …

We developed a radioimmunoassay (RIA) for the carboxy-terminal telopeptides of type I
collagen (ICTP), cross-linked with the helical domain of another type I collagen molecule …

MATERIALS AND METHODS Ten healthy volunteers (6 men, 4 women) aged 27-52 years
took part in this study over a 3 month period (December-February). Non-fasting venous …

Robust validated reference intervals for bone turnover markers (BTMs) are required to
assess fracture risk and effectiveness of therapy. However, there are currently limited …

Collagen is the most abundant protein in the mammalian body and lends structural integrity
to tissues as the primary component of the extracellular matrix (1). Among the many types of …

In order to assess the dynamics of bone turnover during menopausal transition, we
measured the urinary excretion of C-telopeptide (CTX) and N-telopeptide (NTX) of type-I …

Bone turnover markers are subject to day-to-day and within-day variability, which may
influence clinical interpretation. We examined the effect of fasting vs. feeding on the …

Renal osteodystrophy is a major complication in hemodialysis patients. Measurement of
serum peptide derived from the degradation of bone collagen could potentially provide an …

Carboxy-terminal pyridinoline cross-linked telopeptide of type I collagen (ICTP) in serum has
recently been proposed as a new biochemical marker of bone resorption. In the present …