In their midthirties, women experience a decline in fertility, coupled to a pronounced
increase in the risk of aneuploidy, miscarriage, and birth defects. Although the aetiology of …

In brief Post-ovulatory ageing of oocytes leads to poor oocyte and embryo quality as well as
abnormalities in offspring. This review provides an update on the contributions of oxidative …

With extended periods of time following ovulation, the metaphase II stage oocyte
experiences deterioration in quality referred to as post-ovulatory oocyte ageing. Post …

In recent years, postponement of marriage and childbearing in women of reproductive age
has led to an increase in the incidence of age-related infertility. The reproductive aging …

Reproductive capacity in women starts to decline beyond their mid-30s and pregnancies in
older women result in higher rates of miscarriage with aneuploidy. Age-related decline in …

Follicular microenvironment is paramount in the acquisition of oocyte competence, which is
dependent on two interconnected and interdependent processes: nuclear and cytoplasmic …

In a healthy body, reactive oxygen species (ROS) and antioxidants remain balanced. When
the balance is broken toward an overabundance of ROS, oxidative stress appears and may …

It is well established that age-related decline of a woman's fertility is related to the poor
developmental potential of her gametes. The age-associated decline in female fertility is …

The age‐associated decline in female fertility is largely ascribable to a decrease in oocyte
quality. This phenomenon is multifaceted and influenced by numerous interconnected …

Significance: The precipitous age-related decline in female fertility is intimately associated
with a reduction in both the quantity and quality of the germline (oocytes). Although complex …