Stromal-tumor interactions in pancreatic cancer (PC) impact on treatment outcomes.
Pancreatic stellate cells (PSCs) produce the collagenous stroma of PC and interact with …

Background Stromal–tumour interactions facilitate pancreatic cancer (PC) progression. The
hepatocyte growth factor (HGF)/c-MET pathway is upregulated in PC and mediates the …

Pancreatic cancer (PC) is a deadly cancer with a high mortality rate. The unique
characteristics of PC, including desmoplasia and immunosuppression, have made it difficult …

Pancreatic cancer (pancreatic ductal adenocarcinoma (PDAC/PC)) has been an aggressive
disease that is associated with early metastases. It is characterized by dense and …

Background: Pancreatic stellate cells (PSCs, which produce the stroma of pancreatic cancer
(PC)) interact with cancer cells to facilitate PC growth. A candidate growth factor pathway …

Simple Summary It has been previously shown that activation of the MET receptor by its
ligand, the hepatocyte growth factor (HGF), modulates the tumor-stroma cross-talk in models …

Pancreatic ductal adenocarcinoma (PDA) is among the deadliest cancers in the United
States and in the world. Late diagnosis, early metastasis and lack of effective therapy are …

Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with high morbidity and
mortality worldwide. To date, limited therapeutic achievements targeting cell proliferation …

Pancreatic ductal adenocarcinoma (PDA) exhibits one of the poorest prognosis of all solid
tumours and poses an unsolved problem in cancer medicine. Despite the recent success of …

The pancreatic stellate cell (PSC) is the principal cell type of the desmoplastic stroma of
pancreatic ductal adenocarcinoma (PDAC). PSCs interact with cancer cells and influence …