Abstract Background Pancreatic stellate cells (PSCs) play key roles in the pancreatic tumor
microenvironment and are considered to contribute to chemoresistance. PSCs can …

A nearly universal feature of pancreatic ductal adenocarcinoma (PDAC) is an extensive
presence of activated stroma. This stroma is thought to aid in various tumor-promoting …

Pancreatic ductal adenocarcinoma (PDA) is an almost uniformly lethal disease. One
explanation for the devastating prognosis is the failure of many chemotherapies, including …

Pancreatic ductal adenocarcinoma (PDAC) is projected to emerge as the second leading
cause of cancer-related death after 2030. Extreme treatment resistance is perhaps the most …

Pancreatic ductal adenocarcinoma is one of the most aggressive solid malignancies and is
characterized by poor response to current therapy and a dismal survival rate. Recent …

Pancreatic ductal adenocarcinoma is characterised by a dense desmoplastic stroma
composed of stromal cells and extracellular matrix (ECM). This barrier severely impairs drug …

Pancreatic tumor microenvironment (TME) is characterized by poor tumor-vasculature and
extensive desmoplasia that together contribute to poor response to chemotherapy. It was …

Pancreatic ductal adenocarcinoma (PDA) is notoriously aggressive and hard to treat. The
tumour microenvironment (TME) in PDA is highly dynamic and has been found to promote …

Pancreatic cancer is a deadly disease with high mortality due to difficulties in its early
diagnosis and metastasis. The tumor microenvironment induced by interactions between …

Simple Summary Pancreatic cancer has a very low survival rate and improved treatments
are required. In addition to tumour cells, the disease is characterized by a significant non …