[PDF][PDF] Supplemental File S1–Detailed description of computational model
QWAD Arnheim, SD Finley - rs.figshare.com
The model is comprised of three compartments representing the whole mouse (Figure 1):
normal tissue, blood, and tumor tissue. We include human VEGF isoforms (VEGF121 and …
normal tissue, blood, and tumor tissue. We include human VEGF isoforms (VEGF121 and …
[HTML][HTML] Compartment model predicts VEGF secretion and investigates the effects of VEGF trap in tumor-bearing mice
Angiogenesis, the formation of new blood vessels from existing vasculature, is important in
tumor growth and metastasis. A key regulator of angiogenesis is vascular endothelial growth …
tumor growth and metastasis. A key regulator of angiogenesis is vascular endothelial growth …
[HTML][HTML] A two-compartment model of VEGF distribution in the mouse
Vascular endothelial growth factor (VEGF) is a key regulator of angiogenesis–the growth of
new microvessels from existing microvasculature. Angiogenesis is a complex process …
new microvessels from existing microvasculature. Angiogenesis is a complex process …
[HTML][HTML] A compartment model of VEGF distribution in humans in the presence of soluble VEGF receptor-1 acting as a ligand trap
Vascular endothelial growth factor (VEGF), through its activation of cell surface receptor
tyrosine kinases including VEGFR1 and VEGFR2, is a vital regulator of stimulatory and …
tyrosine kinases including VEGFR1 and VEGFR2, is a vital regulator of stimulatory and …
[HTML][HTML] The presence of VEGF receptors on the luminal surface of endothelial cells affects VEGF distribution and VEGF signaling
MO Stefanini, FTH Wu, F Mac Gabhann… - PLoS computational …, 2009 - journals.plos.org
Vascular endothelial growth factor (VEGF) is a potent cytokine that binds to specific
receptors on the endothelial cells lining blood vessels. The signaling cascade triggered …
receptors on the endothelial cells lining blood vessels. The signaling cascade triggered …
[HTML][HTML] A compartment model of VEGF distribution in blood, healthy and diseased tissues
Background Angiogenesis is a process by which new capillaries are formed from pre-
existing blood vessels in physiological (eg, exercise, wound healing) or pathological (eg …
existing blood vessels in physiological (eg, exercise, wound healing) or pathological (eg …
[HTML][HTML] Trafficking dynamics of VEGFR1, VEGFR2, and NRP1 in human endothelial cells
S Sarabipour, K Kinghorn, KM Quigley… - PLOS Computational …, 2024 - journals.plos.org
The vascular endothelial growth factor (VEGF) family of cytokines are key drivers of blood
vessel growth and remodeling. These ligands act via multiple VEGF receptors (VEGFR) and …
vessel growth and remodeling. These ligands act via multiple VEGF receptors (VEGFR) and …
[HTML][HTML] Stacey Finley
A Popel - J Natl Cancer Inst - bioseek.eu
BACKGROUND Vascular endothelial growth factor (VEGF) is known to be a potent promoter
of angiogenesis under both physiological and pathological conditions. Given its role in …
of angiogenesis under both physiological and pathological conditions. Given its role in …
Simulating therapeutics using multiscale models of the VEGF receptor system in cancer
FM Gabhann, MO Stefanini, AS Popel - Modeling tumor vasculature …, 2012 - Springer
Abstract In recent years, Judah Folkman's vision of anticancer therapeutics based on
inhibiting angiogenesis pathways has begun to be realized. In particular, antibodies …
inhibiting angiogenesis pathways has begun to be realized. In particular, antibodies …
Interactions of VEGF isoforms with VEGFR-1, VEGFR-2, and neuropilin in vivo: a computational model of human skeletal muscle
FM Gabhann, AS Popel - American Journal of Physiology …, 2007 - journals.physiology.org
The vascular endothelial growth factor (VEGF) family of cytokines is involved in the
maintenance of existing adult blood vessels as well as in angiogenesis, the sprouting of new …
maintenance of existing adult blood vessels as well as in angiogenesis, the sprouting of new …