Background Signaling via B cell receptor (BCR) and Toll-like receptors (TLRs) results in
activation of B cells with distinct physiological outcomes, but transcriptional regulatory …

Cis-regulomes underlying immune-cell-specific genomic states have been extensively
analyzed by structure-based chromatin profiling. By coupling such approaches with a high …

The progression of hematopoietic stem cells (HSCs) to the B lymphocyte lineage requires
that uncommitted progenitors successfully negotiate the transition from multipotency to …

The genomic loci associated with B cell differentiation that are subject to transcriptional and
epigenetic regulation in vivo are not well defined, leaving a gap in our understanding of the …

B cells exhibit a range of functional responses following TLR engagement including
immunoglobulin and cytokine production, proliferation, antigen presentation and migration …

Background The B cell antigen receptor (BCR) is a signaling complex that mediates the
differentiation of stage-specific cell fate decisions in B lymphocytes. While several studies …

Unlike other immune cells, B cells express both an antigen-specific B cell receptor (BCR)
and Toll-like receptors (TLRs). Dual BCR and TLR engagement can fine-tune functional B …

The transcription factor early B cell factor-1 (Ebf1) is a key determinant of B lineage
specification and differentiation. To gain insight into the molecular basis of Ebf1 function in …

All mature blood cells derive from hematopoietic stem cells through gradual restriction of
their cell fate potential and acquisition of specialized functions. Lineage specification and …

To identify changes in the regulation of B cell receptor (BCR) signals during the
development of human B cells, we generated genome-wide gene expression profiles using …