The M1 and M4 muscarinic acetylcholine receptors (mAChRs) are highly pursued drug
targets for neurological diseases, in particular for Alzheimer's disease and schizophrenia …

The muscarinic acetylcholine receptor (mAChR) subtype 5 (M5) was the most recent
mAChR to be cloned and has since emerged as a potential therapeutic target for a number …

Muscarinic acetylcholine receptors (mAChR) play important roles in regulating complex
behaviors such as cognition, movement, and reward, making them ideally situated as …

Muscarinic acetylcholine receptors (mAChRs) represent exciting therapeutic targets for the
treatment of multiple CNS disorders. The high degree of conservation of amino acids …

Muscarinic acetylcholine receptors (mAChRs) are prototypical Family AG protein coupled-
receptors. The five mAChR subtypes are widespread throughout the periphery and the …

The recently identified small molecule, 3-amino-5-chloro-6-methoxy-4-methylthieno [2, 3-b]
pyridine-2-carboxylic acid cyclopropylamide (LY2033298), is the first selective allosteric …

Allosteric modulation of G protein-coupled receptors (GPCRs) is a major paradigm in drug
discovery. Despite decades of research, a molecular-level understanding of the general …

Benzylquinolone carboxylic acid (BQCA) is the first highly selective positive allosteric
modulator (PAM) for the M 1 muscarinic acetylcholine receptor (mAChR), but it possesses …

Subtype-selective allosteric modulation of the M 1 muscarinic acetylcholine (ACh) receptor
(M 1 mAChR) is an attractive approach for the treatment of numerous disorders, including …

Multiple mechanisms regulate the signaling of the five members of the family of the guanine
nucleotide binding protein (G protein)-coupled muscarinic acetylcholine (ACh) receptors …