Strategies to modulate microRNA functions for the treatment of cancer or organ injury

TJ Lee, X Yuan, K Kerr, JY Yoo, DH Kim, B Kaur… - Pharmacological …, 2020 - ASPET
Cancer and organ injury—such as that occurring in the perioperative period, including acute
lung injury, myocardial infarction, and acute gut injury—are among the leading causes of …

MicroRNA dysregulation in cancer: opportunities for the development of microRNA-based drugs.

SP Nana-Sinkam, CM Croce - IDrugs: the investigational drugs …, 2010 - europepmc.org
MicroRNAs (miRNAs) are 19-to 24-nucleotide, non-coding RNAs that have been implicated
in both solid and hematological malignancies. Given the ability of miRNAs to target multiple …

MicroRNAs in cancer therapeutics: “from the bench to the bedside

PC Monroig-Bosque, CA Rivera… - Expert opinion on …, 2015 - Taylor & Francis
MicroRNAs (miRNAs) are non-coding RNA transcripts that regulate physiological processes
by targeting proteins directly. Their involvement in research has been robust, and evidence …

[HTML][HTML] Modulating microRNAs in cancer: Next-generation therapies

N Arghiani, K Shah - Cancer Biology & Medicine, 2022 - ncbi.nlm.nih.gov
MicroRNAs (miRNAs) are a class of endogenously expressed non-coding regulators of the
genome with an ability to mediate a variety of biological and pathological processes. There …

MicroRNAs as new therapeutic targets and tools in cancer

P Gandellini, V Profumo, M Folini… - Expert opinion on …, 2011 - Taylor & Francis
Introduction: MicroRNAs (miRNAs) are a class of endogenous, non-coding small RNAs that
negatively regulate gene expression at the post-transcriptional level. Several studies have …

Trials and tribulations of MicroRNA therapeutics

AA Seyhan - International Journal of Molecular Sciences, 2024 - mdpi.com
The discovery of the link between microRNAs (miRNAs) and a myriad of human diseases,
particularly various cancer types, has generated significant interest in exploring their …

Advances in the discovery of microRNA-based anticancer therapeutics: latest tools and developments

KKW To, W Fong, CWS Tong, M Wu… - Expert opinion on …, 2020 - Taylor & Francis
Introduction: MicroRNAs (miRNAs) are small endogenous non-coding RNAs that repress the
expression of their target genes by reducing mRNA stability and/or inhibiting translation …

miRNA-based therapeutic strategies

M Ishida, FM Selaru - Current Pathobiology Reports, 2013 - Springer
Micro-RNAs (miRNAs) are short, non-coding RNA species, thought to act primarily through
downregulation of target mRNA species with subsequent decrease in encoded proteins …

Progress in microRNA delivery

Y Zhang, Z Wang, RA Gemeinhart - Journal of controlled release, 2013 - Elsevier
MicroRNAs (miRNAs) are non-coding endogenous RNAs that direct post-transcriptional
regulation of gene expression by several mechanisms. Activity is primarily through binding …

Bottleneck limitations for microRNA-based therapeutics from bench to the bedside

Y Chen, H Zhao, Z Tan, C Zhang… - Die Pharmazie-An …, 2015 - ingentaconnect.com
MicroRNAs are endogenous non-coding small RNAs that repress expression of a broad
array of target genes. Research into the role and underlying molecular events of microRNAs …