Strategies to modulate microRNA functions for the treatment of cancer or organ injury
Cancer and organ injury—such as that occurring in the perioperative period, including acute
lung injury, myocardial infarction, and acute gut injury—are among the leading causes of …
lung injury, myocardial infarction, and acute gut injury—are among the leading causes of …
MicroRNA dysregulation in cancer: opportunities for the development of microRNA-based drugs.
SP Nana-Sinkam, CM Croce - IDrugs: the investigational drugs …, 2010 - europepmc.org
MicroRNAs (miRNAs) are 19-to 24-nucleotide, non-coding RNAs that have been implicated
in both solid and hematological malignancies. Given the ability of miRNAs to target multiple …
in both solid and hematological malignancies. Given the ability of miRNAs to target multiple …
MicroRNAs in cancer therapeutics: “from the bench to the bedside”
PC Monroig-Bosque, CA Rivera… - Expert opinion on …, 2015 - Taylor & Francis
MicroRNAs (miRNAs) are non-coding RNA transcripts that regulate physiological processes
by targeting proteins directly. Their involvement in research has been robust, and evidence …
by targeting proteins directly. Their involvement in research has been robust, and evidence …
[HTML][HTML] Modulating microRNAs in cancer: Next-generation therapies
N Arghiani, K Shah - Cancer Biology & Medicine, 2022 - ncbi.nlm.nih.gov
MicroRNAs (miRNAs) are a class of endogenously expressed non-coding regulators of the
genome with an ability to mediate a variety of biological and pathological processes. There …
genome with an ability to mediate a variety of biological and pathological processes. There …
MicroRNAs as new therapeutic targets and tools in cancer
P Gandellini, V Profumo, M Folini… - Expert opinion on …, 2011 - Taylor & Francis
Introduction: MicroRNAs (miRNAs) are a class of endogenous, non-coding small RNAs that
negatively regulate gene expression at the post-transcriptional level. Several studies have …
negatively regulate gene expression at the post-transcriptional level. Several studies have …
Trials and tribulations of MicroRNA therapeutics
AA Seyhan - International Journal of Molecular Sciences, 2024 - mdpi.com
The discovery of the link between microRNAs (miRNAs) and a myriad of human diseases,
particularly various cancer types, has generated significant interest in exploring their …
particularly various cancer types, has generated significant interest in exploring their …
Advances in the discovery of microRNA-based anticancer therapeutics: latest tools and developments
KKW To, W Fong, CWS Tong, M Wu… - Expert opinion on …, 2020 - Taylor & Francis
Introduction: MicroRNAs (miRNAs) are small endogenous non-coding RNAs that repress the
expression of their target genes by reducing mRNA stability and/or inhibiting translation …
expression of their target genes by reducing mRNA stability and/or inhibiting translation …
miRNA-based therapeutic strategies
M Ishida, FM Selaru - Current Pathobiology Reports, 2013 - Springer
Micro-RNAs (miRNAs) are short, non-coding RNA species, thought to act primarily through
downregulation of target mRNA species with subsequent decrease in encoded proteins …
downregulation of target mRNA species with subsequent decrease in encoded proteins …
Progress in microRNA delivery
Y Zhang, Z Wang, RA Gemeinhart - Journal of controlled release, 2013 - Elsevier
MicroRNAs (miRNAs) are non-coding endogenous RNAs that direct post-transcriptional
regulation of gene expression by several mechanisms. Activity is primarily through binding …
regulation of gene expression by several mechanisms. Activity is primarily through binding …
Bottleneck limitations for microRNA-based therapeutics from bench to the bedside
Y Chen, H Zhao, Z Tan, C Zhang… - Die Pharmazie-An …, 2015 - ingentaconnect.com
MicroRNAs are endogenous non-coding small RNAs that repress expression of a broad
array of target genes. Research into the role and underlying molecular events of microRNAs …
array of target genes. Research into the role and underlying molecular events of microRNAs …