Annotation of prostate cancer genomes provides a foundation for discoveries that can
impact disease understanding and treatment. Concordant assessment of DNA copy number …

Background Understanding the heterogeneous genotypes and phenotypes of prostate
cancer is fundamental to improving the way we treat this disease. As yet, there are no …

Purpose A long natural history and a predominant osseous pattern of metastatic spread are
impediments to the adoption of precision medicine in patients with prostate cancer. To …

Identifying the earliest somatic changes in prostate cancer can give important insights into
tumor evolution and aids in stratifying high-from low-risk disease. We integrated whole …

DNA sequencing has identified recurrent mutations that drive the aggressiveness of prostate
cancers. Surprisingly, the influence of genomic, epigenomic, and transcriptomic …

Background Genomic analyses of hundreds of prostate tumors have defined a diverse
landscape of mutations and genome rearrangements, but the transcriptomic effect of this …

With the advent of next-generation sequencing technologies and large whole-exome and
genome studies in prostate and other cancers, our understanding of the landscape of …

PURPOSE Comprehensive genomic profiling (CGP) is increasingly used for routine clinical
management of prostate cancer. To inform targeted treatment strategies, 3,476 clinically …

Prostate cancer is clinically heterogeneous, ranging from indolent to lethal disease.
Expression profiling previously defined three subtypes of prostate cancer, one (subtype-1) …

Prostate cancer is one of the most common types of cancer among Canadian men. Next-
generation sequencing using RNA-Seq provides large amounts of data that may reveal …