This approach might be extremely useful to investigate in vivo endothelial function in murine
models of vascular diseases and in genetically modified mice. In humans, endothelium …

Objective—Vascular endothelium plays an important role to maintain cardiovascular
homeostasis through several mechanisms, including endothelium-dependent …

AMP-activated protein kinase (AMPK) is a sensor of cellular energy state and a regulator of
cellular homeostasis. In endothelial cells, AMPK is stimulated via the upstream kinases …

Objective—AMP-activated protein kinase (AMPK), an energy and redox sensor, is activated
in response to various cellular stresses, including hypoxia, nutrient deprivation, oxidative …

AMP-activated protein kinase (AMPK) is frequently reported to phosphorylate Ser1177 of the
endothelial nitric-oxide synthase (eNOS), and therefore, is linked with a relaxing effect …

The endothelial isoform of nitric-oxide synthase (eNOS), a key determinant of vascular
homeostasis, is a calcium/calmodulin-dependent phosphoprotein regulated by diverse cell …

Hydrogen peroxide and other reactive oxygen species are intimately involved in endothelial
cell signaling. In many cell types, the AMP-activated protein kinase (AMPK) has been …

Endothelial dysfunction reflects an imbalance of vasodilators and vasoconstrictors.
Endogenous endothelin activity seems to be increased in human obesity and type 2 …

The vascular endothelium secretes factors that not only modulate blood vessel tone, but also
participate in the development and progression of atherosclerosis through their effects on …

Since the first description of the AMP-activated protein kinase (AMPK) more than 20 years
ago, 1 numerous studies have established a pivotal role of this enzyme in the regulation of …