Introduction 3. DNA Hypermethylation, Heterochromatin, and Epigenetic Gene Silencing 4.
DNA Hypomethylation, Demethylation, and Loss of Imprinting 5. DNA Methyltransferases …

Prostate cancer is the most common malignancy and the second leading cause of cancer
death among men in the United States. There are three well-established risk factors for …

Prostate cancer (PCa) is the most prevalent cancer, a significant contributor to morbidity and
a leading cause of cancer-related death in men in Western industrialized countries. In …

Background: Prostate cancer (PCa) harbors a myriad of genomic and epigenetic defects.
Cytosine methylation of CpG-rich promoter DNA is an important mechanism of epigenetic …

Introduction 3. DNA methylation in prostate cancer 3.1. DNA Hypermethylation 3.1. 1.
Hormonal response genes 3.1. 2. Cell cycle control genes 3.1. 3. Tumor invasion and tumor …

Promoter hypermethylation is associated with the loss of expression of tumor-suppressor
genes in cancer. Currently, several genome-wide technologies are available and have been …

The prostate gland is the most common site of cancer and the second leading cause of
cancer death in American men. Recent emerging molecular biological technologies help us …

Epigenetic alterations contribute significantly to the development and progression of
prostate cancer, the most prevalent malignant tumor in males of Western industrialized …

Promoter DNA methylation of CpG islands is an important epigenetic mechanism in cancer
development. We have characterized the promoter methylation profile of 82 genes in three …

Prostate cancer (CaP) is mostly composed of luminal-like differentiated cells, but contains a
small subpopulation of basal cells (including stem-like cells), which can proliferate and …