Long-term T cell-mediated protection depends upon the formation of a pool of memory cells
to protect against future pathogen challenge. In this review we argue that looking at T cell …

Considerable advances have been made in recent years in understanding the generation
and function of memory T cells. Memory T cells are typically parsed into discreet subsets …

Pre-existing T cell memory provides substantial protection against viral, bacterial, and
parasitic infections. The generation of protective T cell memory constitutes a primary goal for …

Our T cell repertoire is shaped by antigen encounter. From a naive T cell pool that contains
millions of different T cells with unknown specificities, pathogen infection leads to selection …

Vaccines, arguably the single most important intervention in improving human health, have
exploited the phenomenon of immunological memory. The elicitation of memory T cells is …

The adaptive immune system has evolved a unique capacity to remember a pathogen
through the generation of memory T cells, which rapidly protect the host in the event of …

After antigenic stimulation in the context of" danger signals," naive T cells embark on a
programmed, intense expansion phase to counteract the rapid proliferation of pathogens …

Adaptive immunity is characterized by the ability to form long-lived immunological memory.
Upon re-exposure to antigen, memory T cells respond more rapidly and robustly than naïve …

The immune system has evolved by continuously increasing its complexity to provide the
host with an advantage over infectious agents. The development of immunological memory …

Immunological memory is manifested by the body's ability to enjoy long-term protection
against specific pathogens previously encountered through illness or vaccination. This …