Understanding how stromal signals regulate the development of pancreatic ductal
adenocarcinoma (PDAC) may suggest novel therapeutic interventions in this disease. In this …

Chronic pancreatitis and pancreatic ductal adenocarcinoma (PDAC) are characterized by
extensive fibrosis. Importantly, in PDAC, this results in poor vascularization and impaired …

Pancreatic ductal adenocarcinoma is one of the deadliest cancers, and its incidence on the
rise. The major challenges in overcoming the poor prognosis with this disease include late …

Pancreatic ductal adenocarcinoma (PDAC) is a gastrointestinal malignancy with a dismal
clinical outcome. Accumulating evidence suggests that activated pancreatic stellate cells …

A nearly universal feature of pancreatic ductal adenocarcinoma (PDAC) is an extensive
presence of activated stroma. This stroma is thought to aid in various tumor-promoting …

Pancreatic ductal adenocarcinoma (PDAC) is a type of cancer with limited treatment options
and terrible long-term survival, and it is expected to become the second leading cause of …

Cancer stem cells (CSCs) play an important role in the clonogenic growth and metastasis of
pancreatic ductal adenocarcinoma (PDAC). A hallmark of PDAC is the desmoplastic …

Pancreatic cancer (PaCa) is characterized by dense stroma that hinders treatment efficacy,
with pancreatic stellate cells (PSCs) being a major contributor to this stromal barrier and …

Pancreatic ductal adenocarcinoma (PDA) is a common and lethal malignancy resulting in
more than 250,000 deaths per year worldwide. Despite extensive efforts, cytotoxic and …

Pancreatic ductal adenocarcinoma (PDAC) frequently presents with metastasis, but the
molecular programs in human PDAC cells that drive invasion are not well understood. Using …