Pancreatic ductal adenocarcinoma (PDAC) is projected to emerge as the second leading
cause of cancer-related death after 2030. Extreme treatment resistance is perhaps the most …

Pancreatic ductal adenocarcinoma (PDA) is characterized by a dense stroma consisting of a
prevalence of activated fibroblasts whose functional contributions to pancreatic …

A fibroinflammatory stromal reaction cooperates with oncogenic signaling to influence
pancreatic ductal adenocarcinoma (PDAC) initiation, progression, and therapeutic outcome …

Stromal-tumor interactions in pancreatic cancer (PC) impact on treatment outcomes.
Pancreatic stellate cells (PSCs) produce the collagenous stroma of PC and interact with …

Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with high morbidity and
mortality worldwide. To date, limited therapeutic achievements targeting cell proliferation …

Pancreatic cancer desmoplasia is thought to confer biological aggressiveness. In this issue
of Cancer Cell, Özdemir and colleagues and Rhim and colleagues demonstrate that …

Pancreatic ductal adenocarcinoma (PDAC) remains a lethal cancer. The poor prognosis
calls for a more detailed understanding of disease biology in order to pave the way for the …

Pancreatic cancer (PC) remains one of the most lethal malignancies worldwide. Increasing
evidence has confirmed the pivotal role of stromal components in the regulation of …

Background/Aim: Pancreatic stellate cells are involved in fibrosis of pancreatic cancer
termed desmoplasia, which may contribute to both pancreatic cancer growth and metastasis …

The stroma of pancreatic ductal adenocarcinoma (PDA) forms a major barrier to therapy and
immune surveillance. Elahi-Gedwillo and colleagues demonstrate that halofuginone has …